Department of Biology, Faculty of Science and Art, Giresun University, Giresun, Turkey.
Department of Food Technology, Sebinkarahisar School of Applied Sciences, Giresun University, Giresun, Turkey.
Environ Sci Pollut Res Int. 2021 Nov;28(44):62868-62876. doi: 10.1007/s11356-021-15097-6. Epub 2021 Jul 3.
Mercury (Hg) is a persistent and dangerous heavy metal with genotoxic properties. Echinacea purpurea L. is a well-known therapeutic plant with anti-inflammatory, antioxidant, and anti-tumor properties. In this study, multi-protective role of Echinacea purpurea L. extract against toxicity caused by mercury(II) chloride (HgCI) on Allium cepa L. investigated in a multifaceted way. As a consequence of 100 mgL HgCI administration, root elongation, weight increase, germination rate, and mitotic index were reduced, whereas micronucleus frequency, chromosomal abnormalities frequency, meristematic cell injuries severity, malondialdehyde level, catalase, and superoxide dismutase activity were increased. On the other hand, co-administration of increasing doses of E. purpurea extract (265 mgL and 530 mgL) and HgCI gradually alleviated all observed toxic effects of HgCI. Protective role of E. purpurea extract against HgCI-toxicity on A. cepa were clearly demonstrated in this study. The results of this study will lead to future researches investigating use of E. purpurea extract against genotoxic contaminants.
汞（Hg）是一种具有遗传毒性的持久性危险重金属。紫锥菊（Echinacea purpurea L.）是一种众所周知的治疗植物，具有抗炎、抗氧化和抗肿瘤特性。在这项研究中，以多方面的方式研究了紫锥菊提取物对汞（II）氯化物（HgCI）引起的毒性的多重保护作用。由于 100 mgL HgCI 的给药，根伸长、重量增加、发芽率和有丝分裂指数降低，而微核频率、染色体异常频率、分生细胞损伤严重程度、丙二醛水平、过氧化氢酶和超氧化物歧化酶活性增加。另一方面，随着紫锥菊提取物（265 mgL 和 530 mgL）剂量的增加，HgCI 的给药逐渐缓解了 HgCI 引起的所有观察到的毒性作用。本研究清楚地证明了紫锥菊提取物对 HgCI 诱导的洋葱根尖细胞毒性的保护作用。这项研究的结果将导致未来对紫锥菊提取物对抗遗传毒性污染物的研究。
