壳聚糖的抗病毒活性综述，包括专利应用及其在对抗 COVID-19 中的潜在用途。
A review of the antiviral activity of Chitosan, including patented applications and its potential use against COVID-19.
机构信息
Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan.
出版信息
J Appl Microbiol. 2022 Jan;132(1):41-58. doi: 10.1111/jam.15202. Epub 2021 Jul 26.
Abstract
Chitosan is an abundant organic polysaccharide, which can be relatively easily obtained by chemical modification of animal or fungal source materials. Chitosan and its derivatives have been shown to exhibit direct antiviral activity, to be useful vaccine adjuvants and to have potential anti-SARS-CoV-2 activity. This thorough and timely review looks at the recent history of investigations into the role of chitosan and its derivatives as an antiviral agent and proposes a future application in the treatment of endemic SARS-CoV-2.
摘要
壳聚糖是一种丰富的有机多糖，可以通过对动物或真菌源材料进行化学修饰相对容易地获得。壳聚糖及其衍生物已被证明具有直接的抗病毒活性，可用作有效的疫苗佐剂，并具有抗 SARS-CoV-2 的潜力。这篇全面及时的综述回顾了近期关于壳聚糖及其衍生物作为抗病毒剂作用的研究，并提出了其在治疗地方性 SARS-CoV-2 方面的未来应用。
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本文引用的文献
1
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Adv Fiber Mater. 2020;2(3):123-139. doi: 10.1007/s42765-020-00047-7. Epub 2020 Jun 23.
2
SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray.使用一种具有黏膜黏附性和两亲性的壳聚糖抑制 SARS-CoV-2，这种壳聚糖可用作抗病毒鼻腔喷雾剂。
Sci Rep. 2021 Oct 8;11(1):20012. doi: 10.1038/s41598-021-99404-8.
3
Chitosan as a machine for biomolecule delivery: A review.壳聚糖作为生物分子递药载体：综述。
Carbohydr Polym. 2021 Mar 15;256:117414. doi: 10.1016/j.carbpol.2020.117414. Epub 2020 Nov 21.
4
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Pathogens. 2021 Jan 5;10(1):36. doi: 10.3390/pathogens10010036.
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Foods. 2021 Jan 8;10(1):121. doi: 10.3390/foods10010121.
6
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Vaccines (Basel). 2020 Dec 22;9(1):1. doi: 10.3390/vaccines9010001.
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Cell Host Microbe. 2021 Feb 10;29(2):236-249.e6. doi: 10.1016/j.chom.2020.12.010. Epub 2020 Dec 16.
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9
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ACS Biomater Sci Eng. 2021 May 10;7(5):1765-1779. doi: 10.1021/acsbiomaterials.0c01291. Epub 2020 Dec 16.
10
Development of vaccines and antivirals for combating viral pandemics.疫苗和抗病毒药物的研发以应对病毒大流行。
Nat Biomed Eng. 2020 Dec;4(12):1128-1133. doi: 10.1038/s41551-020-00658-w.
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