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壳聚糖和壳聚糖作为对抗 COVID-19 的工具:三重方法。

Chitin and chitosan as tools to combat COVID-19: A triple approach.

机构信息

Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Int J Biol Macromol. 2021 Jul 31;183:235-244. doi: 10.1016/j.ijbiomac.2021.04.157. Epub 2021 Apr 27.

Abstract

The progressive and fatal outbreak of the newly emerged coronavirus, SARS-CoV-2, necessitates rigorous collaboration of all health care systems and researchers from all around the world to bring such a devastating pandemic under control. As there is so far no officially approved drug or ideal vaccine for this disease, investigations on this infectious disease are actively pursued. Chitin and chitosan have shown promising results against viral infections. In this review, we first delve into the problematic consequences of viral pandemics followed by an introduction on SARS-CoV-2 taxonomical classification. Then, we elaborate on the immunology of COVID-19. Common antiviral therapies and their related limitations are described and finally, the potential applicability of chitin and chitosan to fight this overwhelming viral pandemic is addressed.

摘要

新型冠状病毒(SARS-CoV-2)的迅速传播和致命性爆发,需要全球所有医疗保健系统和研究人员的紧密合作,以控制这种毁灭性的大流行。由于目前尚无针对这种疾病的官方批准药物或理想疫苗,因此正在积极开展对这种传染病的研究。壳聚糖在抗病毒感染方面显示出了良好的效果。在本综述中,我们首先深入探讨了病毒大流行的问题后果,然后介绍了 SARS-CoV-2 的分类学分类。接着,我们详细阐述了 COVID-19 的免疫学。描述了常见的抗病毒疗法及其相关局限性,最后探讨了壳聚糖在抗击这种压倒性的病毒性大流行中的潜在适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1598/8078037/274de16507b5/gr1_lrg.jpg

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