Anderegg Ulf, Halfter Norbert, Schnabelrauch Matthias, Hintze Vera
Department of Dermatology, Venereology and Allergology, Leipzig University, D-04103 Leipzig, Germany.
Institute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, Budapester Str. 27, D-01069 Dresden, Germany.
Biol Chem. 2021 Jul 5;402(11):1325-1335. doi: 10.1515/hsz-2021-0176. Print 2021 Oct 26.
Wound healing and tissue regeneration are orchestrated by the cellular microenvironment, e.g. the extracellular matrix (ECM). Including ECM components in biomaterials is a promising approach for improving regenerative processes, e.g. wound healing in skin. This review addresses recent findings for enhanced epidermal-dermal regenerative processes on collagen (coll)/glycosaminoglycan (GAG)-based matrices containing sulfated GAG (sGAG) in simple and complex models. These matrices comprise 2D-coatings, electrospun nanofibrous scaffolds, and photo-crosslinked acrylated hyaluronan (HA-AC)/coll-based hydrogels. They demonstrated to regulate keratinocyte and fibroblast migration and growth, to stimulate melanogenesis in melanocytes from the outer root sheath (ORS) of hair follicles and to enhance the epithelial differentiation of human mesenchymal stem cells (hMSC). The matrices' suitability for delivery of relevant growth factors, like heparin-binding epidermal growth factor like growth factor (HB-EGF), further highlights their potential as bioinspired, functional microenvironments for enhancing skin regeneration.
伤口愈合和组织再生由细胞微环境（如细胞外基质（ECM））精心调控。在生物材料中纳入ECM成分是改善再生过程（如皮肤伤口愈合）的一种很有前景的方法。本综述阐述了在简单和复杂模型中，基于含有硫酸化糖胺聚糖（sGAG）的胶原蛋白（coll）/糖胺聚糖（GAG）的基质上，增强表皮 - 真皮再生过程的最新研究结果。这些基质包括二维涂层、电纺纳米纤维支架以及光交联丙烯酸化透明质酸（HA - AC）/胶原蛋白基水凝胶。它们已被证明可调节角质形成细胞和成纤维细胞的迁移与生长，刺激毛囊外根鞘（ORS）黑素细胞中的黑素生成，并增强人间充质干细胞（hMSC）的上皮分化。这些基质对相关生长因子（如肝素结合表皮生长因子样生长因子（HB - EGF））的递送适用性，进一步凸显了它们作为增强皮肤再生的仿生功能性微环境的潜力。
