Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Expert Rev Clin Immunol. 2021 Sep;17(9):1029-1040. doi: 10.1080/1744666X.2021.1952072. Epub 2021 Jul 19.
We conducted a comprehensive analysis to explore whether multiple ( and , polymorphisms and IL proteins (IL-6, IL-10) relate to lung cancer (LC) susceptibility or clinical characteristics.
We performed the standard meta-analysis procedures according to PRISMA. The odds ratio (OR) and mean difference (MD) were used for analysis.
We investigated 11 variants from 43 articles, and found that rs16944 ( = 0.04) and rs1800872 ( = 0.003) decreased while rs1800896 ( = 0.007) increased LC risks. We also found that rs1143627 decreased NSCLC risks ( = 0.03). The heterozygotes and homozygotes contributed differently. In addition, another 15 articles were involved to explore the relationship between IL proteins and LC. We found that LC patients accounted for higher serum IL-6 of 16.60 pg/mL ( < 0.00001) and higher serum IL-10 of 3.47 pg/mL ( = 0.02) than that of controls. Furthermore, IIIA-Ⅳ LC patients tended to have higher proportion of positive IL-6 staining in lung tumor tissue in contrast with IA-IIB patients by TNM stage ( = 0.0002).
Four variants from and , and serum IL-6 and IL-10 levels are associated with LC risks.
我们进行了全面的分析，以探讨多个 （和 、 多态性和白细胞介素蛋白（IL-6、IL-10）是否与肺癌（LC）易感性或临床特征有关。
我们按照 PRISMA 标准进行了荟萃分析程序。使用比值比（OR）和均数差（MD）进行分析。
我们研究了来自 43 篇文章的 11 个变体，发现 rs16944（=0.04）和 rs1800872（=0.003）降低了 LC 风险，而 rs1800896（=0.007）增加了 LC 风险。我们还发现 rs1143627 降低了非小细胞肺癌（NSCLC）的风险（=0.03）。杂合子和纯合子的贡献不同。此外，我们还进行了另外 15 篇文章来探讨白细胞介素蛋白与 LC 的关系。我们发现，LC 患者的血清 IL-6 水平为 16.60 pg/mL（<0.00001），血清 IL-10 水平为 3.47 pg/mL（=0.02），高于对照组。此外，根据 TNM 分期，IIIa-IV 期 LC 患者肺部肿瘤组织中 IL-6 染色阳性的比例高于 IA-IIB 患者（=0.0002）。
、 和中的四个变体以及血清 IL-6 和 IL-10 水平与 LC 风险相关。
