骨外黏液样软骨肉瘤中9q31和22q12.2处的复发性断点。
Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrosarcoma.
作者信息
Turc-Carel C, Dal Cin P, Rao U, Karakousis C, Sandberg A A
机构信息
Roswell Park Memorial Institute, Buffalo, NY.
出版信息
Cancer Genet Cytogenet. 1988 Jan;30(1):145-50. doi: 10.1016/0165-4608(88)90103-3.
PMID:3422040
Abstract
A cytogenetic study of extraskeletal myxoid chondrosarcoma cells revealed a complex t(9;22;15)(q31;q12.2;q25) as a primary chromosome change. A reciprocal translocation involving identical breakpoints on chromosomes #9 and #22 in this tumor has been reported in the literature. We suggest that the breakpoints 9q31 and 22.q12.2 are associated with extraskeletal myxoid chondrosarcoma, a comparatively rare tumor of adulthood.
摘要
一项关于骨外黏液样软骨肉瘤细胞的细胞遗传学研究显示，复杂的t(9;22;15)(q31;q12.2;q25)作为主要染色体改变。文献报道了该肿瘤中涉及9号和22号染色体相同断点的相互易位。我们认为9q31和22.q12.2断点与骨外黏液样软骨肉瘤相关，这是一种相对罕见的成人肿瘤。
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