Ghaffari Javad, Alizadeh-Navaei Reza, Dabaghzadeh Abbas, Ghaffari Negar
Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Gastrointestinal Cancer Research Center, Mazandarn University of Medical Sciences, Sari, Iran.
Caspian J Intern Med. 2021 Apr;12(3):236-242. doi: 10.22088/cjim.12.3.236.
Asthma is a chronic inflammatory respiratory disorder. Nutritional conditions affect allergic diseases such as asthma. The aim of this study was to review the serum zinc level in children with asthma.
This is a review article found in databases such as Google, PubMed, SID, Irandoc, Scopus and up-to-date. Key words for search included zinc, asthma, children and pediatric. There was no time limitation for the search. These articles on zinc levels in asthmatic children were meta-analyzed.
Out of the 40 articles, 19 articles were excluded and 21 articles were included in this analysis. 15 articles evaluated serum zinc levels, 4 articles on hair zinc levels, one article evaluated nail zinc levels and another on zinc level in erythrocyte cells in children with asthma. Only 3 articles evaluated effects of zinc supplement treatment in children with asthma. Meta-analysis of studies showed that there was no significant difference between the standard mean differences of zinc level in asthmatic patients compared to the control group. We cannot analyze the association between zinc levels in hair and nail in children with asthma. All clinical trial studies show that zinc supplement improves clinical manifestations of asthma and patient's pulmonary function test.
We found that the mean serum zinc level difference is not significant in children with asthma than healthy control group and it seems that there is no relation between mean serum zinc level and severity of asthma in children.
哮喘是一种慢性炎症性呼吸系统疾病。营养状况会影响诸如哮喘之类的过敏性疾病。本研究的目的是回顾哮喘患儿的血清锌水平。
这是一篇在谷歌、PubMed、SID、伊朗文档、Scopus等数据库以及最新资料中找到的综述文章。搜索关键词包括锌、哮喘、儿童和儿科。搜索没有时间限制。对这些关于哮喘患儿锌水平的文章进行荟萃分析。
在40篇文章中，排除了19篇，本分析纳入了21篇。15篇文章评估了血清锌水平，4篇关于头发锌水平，1篇评估了指甲锌水平，另一篇关于哮喘患儿红细胞中的锌水平。只有3篇文章评估了锌补充剂治疗对哮喘患儿的影响。研究的荟萃分析表明，与对照组相比，哮喘患者锌水平的标准平均差异没有显著差异。我们无法分析哮喘患儿头发和指甲中锌水平之间的关联。所有临床试验研究表明，补充锌可改善哮喘的临床表现和患者的肺功能测试。
我们发现，哮喘患儿的平均血清锌水平差异与健康对照组相比并不显著，而且儿童平均血清锌水平与哮喘严重程度之间似乎没有关联。
