Chen Ziwei, He Jing, Chen Chu, Lu Qi
Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, China.
Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.
Front Cardiovasc Med. 2021 Jun 18;8:670768. doi: 10.3389/fcvm.2021.670768. eCollection 2021.
The study aims to investigate the association of total bilirubin with all-cause and cause-specific mortality in the general population. A total of 37,234 adults from the United States National Health and Nutrition Examination Survey 1999-2014 were enrolled. Baseline levels of total bilirubin associated with risk of mortality were evaluated on a continuous scale (restricted cubic splines) and by quartile categories with Cox regression models. Higher levels of total bilirubin was positively associated with an increased risk of all-cause mortality [hazard ratio (HR) 1.59, 95% confidence interval (CI) 1.46-1.72; < 0.001]. Compared with individuals with the lowest quartile of bilirubin, the multivariable adjusted hazard ratio for all-cause mortality was 1.25 (1.14-1.37) for individuals in the highest quartile. Restricted cubic splines indicated that the association was non-linear in cardiovascular mortality and cancer mortality while linear in all-cause mortality. Total bilirubin was associated with all-cause and cause-specific mortality in the general population.
该研究旨在调查普通人群中总胆红素与全因死亡率及特定病因死亡率之间的关联。研究纳入了来自1999 - 2014年美国国家健康与营养检查调查的37234名成年人。通过连续尺度（受限立方样条）以及四分位数类别，采用Cox回归模型评估与死亡率风险相关的总胆红素基线水平。较高的总胆红素水平与全因死亡率风险增加呈正相关[风险比（HR）1.59，95%置信区间（CI）1.46 - 1.72；P < 0.001]。与胆红素最低四分位数的个体相比，最高四分位数个体的全因死亡率多变量调整风险比为1.25（1.14 - 1.37）。受限立方样条表明，该关联在心血管疾病死亡率和癌症死亡率方面呈非线性，而在全因死亡率方面呈线性。总胆红素与普通人群的全因死亡率及特定病因死亡率相关。
