Asfar Taghrid, Koru-Sengul Tulay, Annane Debra, McClure Laura A, Perez Amanda, Antoni Michael A, Brewer Judson, Lee David J
Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St, 9th Floor, Miami, FL, 33136, USA.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1120 NW 14th St, 9th Floor, Miami, FL, 33136, USA.
Contemp Clin Trials Commun. 2021 May 19;22:100784. doi: 10.1016/j.conctc.2021.100784. eCollection 2021 Jun.
Approximately 45% of young cancer survivors (18-40 years) are cigarette smokers. Continued smoking after cancer diagnosis leads to lower survival rates. A major logistical problem with smoking cessation efforts in this group is their geographic dispersion which makes them hard to reach. In addition, depression is a major predictor of smoking relapse and its rates are roughly twice as high in cancer survivors as the general population. Smartphone applications (apps) show promise in terms of efficacy, dissemination, and improving access to treatment. Mindfulness training (defined as maintaining attention on one's immediate experience and cultivating an attitude of acceptance toward this experience) is effective in improving smoking cessation outcomes by reducing psychological stress and controlling craving. Given that smartphone apps can address the issues of mobility and remote access, and mindfulness can address the high depression rate among cancer survivors, validating the feasibility and efficacy of a mindfulness-based smoking cessation intervention app in young cancer survivors is a high priority. Thus, the aims of the current study are: (1) test the feasibility, acceptability, and potential efficacy of the mindfulness-based smoking cessation app versus in-person mindfulness or usual care in a 3-arm pilot randomized clinical trial among young cancer survivors (n = 60; 18-40 years); and 2) conduct semi-structured exit interviews with participants in the two mindfulness groups to fine-tune the two active interventions based on feedback from participants. Findings will have implications for the development and dissemination of innovative and highly scalable tobacco cessation interventions designed for young cancer survivors.
大约45%的年轻癌症幸存者（18至40岁）吸烟。癌症诊断后继续吸烟会导致生存率降低。该群体戒烟工作的一个主要后勤问题是他们居住分散，难以接触到。此外，抑郁症是吸烟复发的主要预测因素，癌症幸存者中的抑郁症发病率大约是普通人群的两倍。智能手机应用程序（应用）在疗效、传播以及改善治疗可及性方面显示出前景。正念训练（定义为将注意力保持在个人当下的体验上，并培养对这种体验的接纳态度）通过减轻心理压力和控制渴望，能有效改善戒烟效果。鉴于智能手机应用可以解决移动性和远程获取的问题，而正念可以解决癌症幸存者中抑郁症发病率高的问题，验证一款基于正念的戒烟干预应用在年轻癌症幸存者中的可行性和疗效是当务之急。因此，本研究的目的是：（1）在一项针对年轻癌症幸存者（n = 60；18至40岁）的三臂试点随机临床试验中，测试基于正念的戒烟应用与面对面正念训练或常规护理相比的可行性、可接受性和潜在疗效；（2）对两个正念组的参与者进行半结构化退出访谈，根据参与者的反馈对两种积极干预措施进行微调。研究结果将为针对年轻癌症幸存者开发和推广创新且具有高度可扩展性的戒烟干预措施提供参考。
