Syrjänen S, Valle S L, Antonen J, Suni J, Saxinger C, Krohn K, Ranki A
Institute of Dentistry, University of Kuopio, Finland.
Oral Surg Oral Med Oral Pathol. 1988 Jan;65(1):36-40. doi: 10.1016/0030-4220(88)90188-0.
The oral mucosae of 66 homosexual men were examined clinically and by means of cultivation to determine the presence of Candida infection. In addition, clinically detected mucosal changes were recorded and a biopsy specimen was obtained for the histopathologic classification. A total of forty one subjects (62%) showed clinical evidence of candidiasis. Fourteen (21%) of the sixty-six men were seropositive for human immunodeficiency virus (HIV). A total of thirteen of fourteen (93%) of the seropositive men and twenty-six of fifty-two (50%) of the HIV seronegative men had culture-confirmed oral candidiasis. In the latter group, oral candidiasis was clearly correlated to cigarette smoking. Clinical mucosal changes other than candidiasis were found in forty-five of the sixty-six subjects studied. The most frequent finding was trauma resulting from biting, which was usually localized on the cheek. Leukoplakia was found in twelve of sixty-six subjects, while cauliflower-like condylomas were present in 4 persons. The results emphasize the frequent occurrence of different oral lesions in subjects seropositive for HIV and in those at high risk for HIV infection. Oral examination in search for potential early manifestations of HIV infection in homosexual men is advocated.
对66名男同性恋者的口腔黏膜进行了临床检查及培养，以确定是否存在念珠菌感染。此外，记录临床检测到的黏膜变化，并获取活检标本进行组织病理学分类。共有41名受试者（62%）有念珠菌病的临床证据。66名男性中有14名（21%）人类免疫缺陷病毒（HIV）血清学检测呈阳性。14名血清学阳性男性中有13名（93%）以及52名HIV血清学阴性男性中有26名（50%）经培养确诊为口腔念珠菌病。在后一组中，口腔念珠菌病与吸烟明显相关。在66名研究对象中，有45名出现了除念珠菌病以外的临床黏膜变化。最常见的发现是咬伤造成的创伤，通常位于脸颊。66名受试者中有12名发现有白斑，4人有菜花状湿疣。结果强调了HIV血清学阳性者及HIV感染高危人群中不同口腔病变的频繁发生。提倡对男同性恋者进行口腔检查，以寻找HIV感染潜在的早期表现。
