Université de Lorraine, INRAE, USC 340, UR AFPA, 54000, Nancy, France.
INTHERES, Université de Toulouse, INRAE, ENVT, 31076, Toulouse, France.
Environ Toxicol Pharmacol. 2021 Oct;87:103698. doi: 10.1016/j.etap.2021.103698. Epub 2021 Jul 2.
To reduce the exposure of the French West Indies population to the organochlorine insecticide chlordecone (Kepone; CLD), the contamination of currently consumed foodstuffs must be reduced. Depuration of contaminated animals before slaughter could be a strategy to obtain safe animal products. The aim of this study was to characterize and quantify CLD elimination in contaminated ewes during depuration process. Experiments A and B consisted in a single intravenous (i.v.) administration of CLD (n = 5) and CLDOH (chlordecol; n = 3) followed by a 84-d and 3-d depuration period respectively with collection of blood, faeces and urine samples. After CLD administration, CLD and conjugated-CLDOH (CLDOH-C) were quantified in serum and urine and CLD and CLDOH were quantified in faeces. Based on calculations of faecal, urinary and body clearances of CLD and CLDOH-C, faeces appeared as the major route of CLD excretion with 86 % of the CLD administered dose eliminated in faeces, either as CLD (51 %) or as CLDOH (35 %).
为了降低法属西印度群岛人群接触有机氯杀虫剂氯丹（Kepone；CLD）的风险，必须减少目前食用的食物中的污染。在屠宰前对受污染的动物进行净化可能是获得安全动物产品的一种策略。本研究的目的是在净化过程中描述并量化受污染的母羊体内 CLD 的消除情况。实验 A 和 B 分别包括单次静脉（i.v.）给予 CLD（n = 5）和 CLDOH（氯丹醇；n = 3），随后进行 84 天和 3 天的净化期，并采集血液、粪便和尿液样本。CLD 给药后，在血清和尿液中定量检测 CLD 和共轭-CLDOH（CLDOH-C），在粪便中定量检测 CLD 和 CLDOH。根据 CLD 和 CLDOH-C 的粪便、尿液和身体清除率的计算，粪便似乎是 CLD 排泄的主要途径，86%的给予剂量的 CLD 以 CLD（51%）或 CLDOH（35%）的形式排泄到粪便中。
