Université de Lorraine, INRA, USC 340, UR AFPA, 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy Cedex, France.
Université de Lorraine, INRA, USC 340, UR AFPA, 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy Cedex, France.
Chemosphere. 2017 Mar;171:564-570. doi: 10.1016/j.chemosphere.2016.12.054. Epub 2016 Dec 13.
The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution of soils. CLD is known to be potentially transferred towards animal products of animals reared outdoors, mainly through accidental soil ingestion. Several studies indicate that soil bound CLD is bioavailable when administered to farm animals. Currently there is a need to quantify the level of CLD absorption and its toxicokinetic characteristics in the ruminant and particularly in the goat. These are considered as important farm species in the French West Indies. The objective of this study was to evaluate the absorption rate and the half-life of CLD in the non-lactating goat. The goats were administered either intravenously (i.v., n = 6) or orally (p.o., n = 6) one dose (1 mg kg body weight) of CLD. Blood samples were collected at defined times up to 160 days post-dosing. CLD was analyzed in serum by high-resolution gas chromatography. A comparison of the area under the serum concentration-time curves (AUC) showed that the i.v. route is equivalent to the oral route. Thus, CLD is considered almost completely absorbed after p.o. administration, as shown by the mean absolute bioavailability. The comparison between the pharmacokinetic profiles of CLD following oral and intravenous dose showed a difference during the first 14 days and a similar kinetic after this period. The half-life of CLD in serum was close to 20 days. These results highlight a possible strategy of decontamination due to the short half-life of CLD, obtained in dry goats that did not excrete fat matter.
氯丹（CLD）在法属西印度群岛的先前使用导致了土壤的长期污染。已知 CLD 可能通过动物意外摄入土壤而转移到户外饲养的动物的动物产品中。几项研究表明，当给予农场动物时，土壤结合的 CLD 是生物可利用的。目前，需要量化反刍动物（特别是山羊）中 CLD 的吸收水平及其毒代动力学特征。这些被认为是法属西印度群岛的重要农场物种。本研究的目的是评估非泌乳山羊中 CLD 的吸收速率和半衰期。山羊经静脉内（i.v.，n=6）或口服（p.o.，n=6）给予 CLD 单剂量（1mg/kg 体重）。在给药后 160 天内，在规定的时间采集血样。通过高分辨率气相色谱法在血清中分析 CLD。比较血清浓度-时间曲线下面积（AUC）表明，静脉内途径与口服途径等效。因此，口服给药后 CLD 几乎被完全吸收，如平均绝对生物利用度所示。口服和静脉内剂量后 CLD 的药代动力学曲线之间的比较表明，在前 14 天期间存在差异，在此期间之后具有相似的动力学。CLD 在血清中的半衰期接近 20 天。这些结果突出了由于在未排出脂肪物质的干燥山羊中 CLD 的半衰期短，可能存在的去污策略。
