Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China.
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Cell Death Dis. 2021 Jul 5;12(7):674. doi: 10.1038/s41419-021-03967-3.
Parkinson's disease is a common neurodegenerative disease. Cell transplantation is a promising therapeutic option for improving the survival and function of dopaminergic neurons, but the mechanisms underlying the interaction between the transplanted cells and the recipient neurons remain to be studied. In this study, we investigated the effects of skin precursor cell-derived Schwann cells (SKP-SCs) directly cocultured with 6-OHDA-injured dopaminergic neurons in vitro and of SKP-SCs transplanted into the brains of 6-OHDA-induced PD mice in vivo. In vitro and in vivo studies revealed that SKP-SCs could reduce the damage to dopaminergic neurons by enhancing self-autophagy and modulating neuronal autophagy. Thus, the present study provides the first evidence that cell transplantation mitigates 6-OHDA-induced damage to dopaminergic neurons by enhancing self-autophagy, suggesting that earlier transplantation of Schwann cells might help alleviate the loss of dopaminergic neurons.
帕金森病是一种常见的神经退行性疾病。细胞移植是一种有前途的治疗选择，可以改善多巴胺能神经元的存活和功能，但移植细胞与受者神经元相互作用的机制仍有待研究。在这项研究中，我们研究了直接与 6-OHDA 损伤的多巴胺能神经元共培养的皮肤前体细胞衍生的施万细胞 (SKP-SCs) 的作用，以及将 SKP-SCs 移植到 6-OHDA 诱导的 PD 小鼠脑内的作用。体外和体内研究表明，SKP-SCs 可以通过增强自噬和调节神经元自噬来减轻多巴胺能神经元的损伤。因此，本研究首次提供证据表明，细胞移植通过增强自噬来减轻 6-OHDA 诱导的多巴胺能神经元损伤，提示早期移植施万细胞可能有助于减轻多巴胺能神经元的丢失。
