Szabad J, Reuter G, Schröder M B
Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged.
Mol Gen Genet. 1988 Jan;211(1):56-62. doi: 10.1007/BF00338393.
We have studied the developmental effects of two dominant suppressor mutations of position-effect variegation mutations on female germ-line cells. Su-var(2)1(01), which has been shown to affect chromatin structure though altering histone deacetylation, and Su-var(3)3(03) are recessive female steriles and zygotic lethals in the presence of butyrate or an additional Y chromosome. We have analysed mosaic females with mutant germ-line and normal soma and concluded that intact functions of the Su-var(2)1 and the Su-var(3)3 genes are required for development of both the soma and the germ-line and that as indirect evidence suggest, their maternally provided products are needed for normal embryonic development. It is suggested that there is possibly a common control of chromatin structure and gene expression in the soma, female germ-line and embryonic cells of Drosophila.
我们研究了位置效应斑驳突变的两个显性抑制突变对雌性生殖系细胞的发育影响。Su-var(2)1(01)已被证明通过改变组蛋白去乙酰化来影响染色质结构，而Su-var(3)3(03)在存在丁酸盐或额外的Y染色体时是隐性雌性不育和合子致死突变。我们分析了具有突变生殖系和正常体细胞的嵌合雌性，得出结论：Su-var(2)1和Su-var(3)3基因的完整功能对于体细胞和生殖系的发育都是必需的，并且如间接证据所示，它们由母体提供的产物对于正常胚胎发育是必需的。有人提出，果蝇的体细胞、雌性生殖系和胚胎细胞中可能存在对染色质结构和基因表达的共同控制。
