Reuter G, Dorn R, Hoffmann H J
Mol Gen Genet. 1982;188(3):480-5. doi: 10.1007/BF00330052.
Mutations at a locus on chromosome II of D. melanogaster suppressing position-effect variegation mutations have been identified which display recessive butyrate sensitivity. Survival of homozygous mutant flies is significantly reduced on medium containing sodium n-butyrate. The butyrate sensitive suppressor mutations are further characterized by recessive female sterility and reduced survival of homozygotes. Complementation analysis showed their allelism. The locus of these mutations, Su-var (2) 1, has been localized to 40.5 +/- 0.2 and, by using interstitial duplications, to region 31CD on the cytogenetic map. Moreover, the mutant alleles of the Su-var (2) 1 locus display a lethal interaction with the heterochromatic Y chromosome. The presence or absence of a Y chromosome in males or females has a strong influence on the viability of homozygous or transheterozygous suppressor flies. All the genetic properties of Su-var (2) 1 mutants suggest strongly that this locus affects chromosome condensation.
已鉴定出黑腹果蝇（D. melanogaster）二号染色体上一个抑制位置效应斑驳突变的位点发生的突变，这些突变表现出隐性丁酸盐敏感性。在含有正丁酸钠的培养基上，纯合突变果蝇的存活率显著降低。丁酸盐敏感抑制突变的进一步特征是隐性雌性不育和纯合子存活率降低。互补分析显示了它们的等位性。这些突变的位点，即Su-var(2)1，已定位到40.5±0.2，并通过使用中间重复，定位到细胞遗传学图谱上的31CD区域。此外，Su-var(2)1位点的突变等位基因与异染色质Y染色体表现出致死相互作用。雄性或雌性中Y染色体的存在与否对纯合或反式杂合抑制果蝇的活力有很大影响。Su-var(2)1突变体的所有遗传特性都强烈表明该位点影响染色体凝聚。
