NIHR Nottingham BRC Respiratory Theme, School of Medicine, University of Nottingham, Nottingham, UK.
Division of Epidemiology, School of Medicine, University of Nottingham, Nottingham, UK.
Chron Respir Dis. 2021 Jan-Dec;18:1479973121994572. doi: 10.1177/1479973121994572.
While chronic lung disease causes substantial global morbidity and mortality, global estimates have primarily been based on broad assumptions. Specific country data from low-income countries such as Nepal are limited. This review assessed primary evidence on chronic respiratory disease burden among adults in Nepal. A systematic search was performed in June 2019 (updated May 2020) for studies through nine databases. High levels of heterogeneity deemed a narrative synthesis appropriate. Among 27 eligible studies identified, most were low-moderate quality with cross-sectional and retrospective study design. Chronic lung diseases identified were chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis and restrictive lung diseases. Studies were categorised as: (i) community-based, (ii) hospital-based and (iii) comorbidity-related and disease burden. Reported disease prevalence varied widely (COPD, 1.67-14.3%; asthma, 4.2-8.9%). The prevalence of airflow obstruction was higher among rural dwellers (15.8%) and those exposed to household air pollution from domestic biomass burning as opposed to liquid petroleum gas users (Odds Ratio: 2.06). Several comorbidities, including hypertension and diabetes mellitus added to the disease burden. The review shows limited literature on lung disease burden in Nepal. Publications varied in terms of overall quality. Good quality research studies with prospective cohorts related to respiratory conditions are required.
虽然慢性肺部疾病会导致全球大量的发病率和死亡率，但全球估计主要基于广泛的假设。尼泊尔等低收入国家的具体国家数据有限。本综述评估了尼泊尔成年人慢性呼吸道疾病负担的主要证据。2019 年 6 月（2020 年 5 月更新）通过九个数据库进行了系统搜索。由于存在高度异质性，因此认为叙述性综合分析是合适的。在确定的 27 项合格研究中，大多数研究质量为低中度，设计为横断面和回顾性研究。确定的慢性肺部疾病包括慢性阻塞性肺疾病（COPD）、哮喘、支气管扩张和限制性肺疾病。研究分为：（i）基于社区，（ii）基于医院，（iii）与合并症相关和疾病负担。报告的疾病患病率差异很大（COPD，1.67-14.3%；哮喘，4.2-8.9%）。农村居民（15.8%）和暴露于家用生物质燃烧而非液化石油气的人（比值比：2.06）的气流阻塞患病率较高。几种合并症，包括高血压和糖尿病，加重了疾病负担。该综述表明，尼泊尔关于肺部疾病负担的文献有限。出版物在整体质量方面存在差异。需要进行与呼吸道疾病相关的前瞻性队列的高质量研究。
