Gene Therapy Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Regenerative Medicine group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran; School of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia; Regenerative Medicine group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Biomed Pharmacother. 2021 Sep;141:111875. doi: 10.1016/j.biopha.2021.111875. Epub 2021 Jul 3.
Cancer stands as one of the most leading causes of death worldwide, while one of the most significant challenges in treating it is revealing novel alternatives to predict, diagnose, and eradicate tumor cell growth. Although various methods, such as surgery, chemotherapy, and radiation therapy, are used today to treat cancer, its mortality rate is still high due to the numerous shortcomings of each approach. Regenerative medicine field, including tissue engineering, cell therapy, gene therapy, participate in cancer treatment and development of cancer models to improve the understanding of cancer biology. The final intention is to convey fundamental and laboratory research to effective clinical treatments, from the bench to the bedside. Proper interpretation of research attempts helps to lessen the burden of treatment and illness for patients. The purpose of this review is to investigate the role of regenerative medicine in accelerating and improving cancer treatment. This study examines the capabilities of regenerative medicine in providing novel cancer treatments and the effectiveness of these treatments to clarify this path as much as possible and promote advanced future research in this field.
癌症是全球主要死因之一，而治疗癌症的最大挑战之一是寻找新的方法来预测、诊断和消除肿瘤细胞生长。尽管目前有手术、化疗和放疗等多种方法用于治疗癌症，但由于每种方法都存在许多缺点，其死亡率仍然很高。再生医学领域，包括组织工程、细胞疗法、基因疗法，参与癌症治疗和癌症模型的开发，以提高对癌症生物学的理解。最终目的是将基础和实验室研究转化为有效的临床治疗，从实验室到临床。正确解读研究尝试有助于减轻患者的治疗和疾病负担。本综述旨在探讨再生医学在加速和改善癌症治疗中的作用。本研究考察了再生医学在提供新的癌症治疗方法方面的能力以及这些治疗方法的有效性，以尽可能清楚地阐明这一途径，并促进该领域的进一步研究。
