Department of Pathology, Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Pathology, Faculty of Medicine, King Abdulaziz University, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia.
Libyan J Med. 2021 Dec;16(1):1949798. doi: 10.1080/19932820.2021.1949798.
This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies.A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays.Leptin was up-regulated during transformation and was identified as brown cytoplasmic granules in the malignant urothelium of 123 (96%) bladder neoplasms, of which 68 (53.1%) cases showed high levels (moderate to strong) of staining. Strong staining was found to be associated with high stages (P = 0.001), muscularis propria infiltration (P < 0.001), vascular invasion (P < 0.03), lymph node involvement (P < 0.02), metastases (P < 0.05), and mortality (P < 0.03). Furthermore, various important survival distributions were detected with leptin expression in the malignant urothelium (P < 0.03).These pilot results suggest that leptin might be a valid marker for predicting the stage and bad prognoses in bladder carcinoma.
本研究探讨了膀胱癌中瘦素的表达及其在膀胱癌诊断和预后中的作用。本研究使用了一组 128 例膀胱癌病例和 24 例正常膀胱标本，通过组织微阵列的免疫组织化学方法研究了瘦素的表达。瘦素在转化过程中上调，并在 123 例（96%）膀胱癌恶性尿路上皮中被鉴定为棕色细胞质颗粒，其中 68 例（53.1%）病例显示高染色水平（中度至强）。强染色与高分期（P = 0.001）、固有肌层浸润（P < 0.001）、血管侵犯（P < 0.03）、淋巴结受累（P < 0.02）、转移（P < 0.05）和死亡率（P < 0.03）有关。此外，在恶性尿路上皮中检测到瘦素表达与各种重要的生存分布有关（P < 0.03）。这些初步结果表明，瘦素可能是预测膀胱癌分期和不良预后的有效标志物。
