Duan Xiaofeng, Tang Peng, Zhang Hongdian, Yu Zhentao
Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin 300060, China.
Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin 300060, China. Email:
Zhonghua Zhong Liu Za Zhi. 2014 Nov;36(11):839-43.
To preliminarily investigate the expression and clinical significance of leptin and adiponectin in esophageal squamous cell carcinoma (ESCC).
The expression of leptin and adiponectin in ESCC and normal esophageal mucosal tissue was detected by immunohistochemical staining with tissue microarray. The correlation between leptin, adiponectin and clinicalpathological features was statistically analyzed.
The expression of leptin was significantly upregulated in the ESCC than in the normal esophageal mucosa tissue [65.6% (80/122) versus 27.5% (11/40), P < 0.001]. Expression of leptin was significantly correlated with lymph node involvement and advanced tumor stage (P = 0.009 and P = 0.043, respectively). Expression of adiponectin was significantly down-regulated in ESCC compared with that in normal esophageal mucosal tissue [22.1% (27/122) versus 47.5% (19/40), P = 0.002]. Expression of adiponectin was significantly correlated with lymph node involvement (P = 0.020). Correlation analysis showed a positive correlation between the expression of leptin and lymph node metastasis and TNM stage (r = 0.235 and r = 0.183, respectively), and a negative correlation between the expression of adiponectin and lymph node metastasis (r = -0.229). There was no significant correlation between the expressions of leptin and adiponectin (P > 0.05), and between the body mass index and the expression of leptin and adiponectin, and lymph node metastasis (P > 0.05 for all).
An imbalanced expression of adipocytokines exits in ESCC. The expression of leptin and adiponectin is correlated with lymph node metastasis and/or tumor stage. Therefore, imbalanced expression of leptin and adiponectin may have a potential role in the carcinogenesis and disease progression of ESCC.
初步探讨瘦素和脂联素在食管鳞状细胞癌（ESCC）中的表达及临床意义。
采用组织芯片免疫组化染色法检测ESCC组织及正常食管黏膜组织中瘦素和脂联素的表达。对瘦素、脂联素与临床病理特征之间的相关性进行统计学分析。
ESCC组织中瘦素的表达明显高于正常食管黏膜组织[65.6%（80/122）对27.5%（11/40），P<0.001]。瘦素表达与淋巴结转移及肿瘤晚期显著相关（分别为P=0.009和P=0.043）。与正常食管黏膜组织相比，ESCC组织中脂联素的表达明显下调[22.1%（27/122）对47.5%（19/40），P=0.002]。脂联素表达与淋巴结转移显著相关（P=0.020）。相关性分析显示，瘦素表达与淋巴结转移及TNM分期呈正相关（分别为r=0.235和r=0.183），脂联素表达与淋巴结转移呈负相关（r=-0.229）。瘦素与脂联素的表达之间无显著相关性（P>0.05），体重指数与瘦素、脂联素的表达及淋巴结转移之间也无显著相关性（均为P>0.05）。
ESCC中存在脂肪细胞因子表达失衡。瘦素和脂联素的表达与淋巴结转移和/或肿瘤分期相关。因此，瘦素和脂联素的表达失衡可能在ESCC的致癌作用和疾病进展中发挥潜在作用。
