中度酒精性肝炎。
Moderate Alcoholic Hepatitis.
机构信息
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center (UPMC), BST West 11th Floor, Suite 1116-17, 200 Lothrop Street, Pittsburgh, PA 15213, USA; CIBERehd, Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pavilion 11th, Floor 0, Madrid 28029, Spain.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center (UPMC), BST West 11th Floor, Suite 1116-17, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
出版信息
Clin Liver Dis. 2021 Aug;25(3):537-555. doi: 10.1016/j.cld.2021.03.001. Epub 2021 May 27.
The natural history of moderate alcoholic hepatitis (AH) is not well known. It is a frequent disease with a probable underestimated incidence compared with its severe form. Among the different prognostic scores predicting short-term mortality in AH, MELD seems to be the most accurate. The mortality of moderate AH is 3% to 7% in the short to medium term and 13% to 20% at 1 year, mainly because of liver-related complications, including severe infections. Long-term abstinence is the main goal of the treatment. There is still need for the development of new therapies for AH, including the less severe forms.
中度酒精性肝炎（AH）的自然病程尚不明确。该病较为常见，但与重症 AH 相比，其发病率可能被低估。在预测 AH 短期死亡率的不同预后评分中，MELD 似乎是最准确的。中度 AH 的短期至中期死亡率为 3%至 7%，1 年死亡率为 13%至 20%，主要原因是与肝脏相关的并发症，包括严重感染。长期戒酒是治疗的主要目标。仍需要开发新的治疗方法，包括针对病情较轻的 AH 的治疗方法。
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