Brain Language Laboratory, 9166Freie Universität Berlin, Berlin, Germany.
Einstein Center for Neurosciences, Berlin, Germany.
Neurorehabil Neural Repair. 2021 Oct;35(10):861-870. doi: 10.1177/15459683211029235. Epub 2021 Jul 7.
Intensive aphasia therapy can improve language functions in chronic aphasia over a short therapy interval of 2-4 weeks. For one intensive method, , beneficial effects are well documented by a range of randomized controlled trials. However, it is unclear to date whether therapy-related improvements are maintained over years. The current study aimed at investigating long-term stability of ILAT treatment effects over circa 1-2 years (8-30 months). 38 patients with chronic aphasia participated in ILAT and were re-assessed at a follow-up assessment 8-30 months after treatment, which had been delivered 6-12.5 hours per week for 2-4 weeks. A standardized clinical aphasia battery, the Aachen Aphasia Test, revealed significant improvements with ILAT that were maintained for up to 2.5 years. Improvements were relatively better preserved in comparatively young patients (<60 years). Measures of communicative efficacy confirmed improvements during intensive therapy but showed inconsistent long-term stability effects. The present data indicate that gains resulting from intensive speech-language therapy with ILAT are maintained up to 2.5 years after the end of treatment. We discuss this novel finding in light of a possible move from sparse to intensive therapy regimes in clinical practice.
强化失语症疗法可以在 2-4 周的短期治疗时间内改善慢性失语症的语言功能。对于一种强化方法,一系列随机对照试验充分证明了其有益效果。然而,目前尚不清楚治疗相关的改善是否能持续多年。本研究旨在调查 ILAT 治疗效果在大约 1-2 年内(8-30 个月)的长期稳定性。38 名慢性失语症患者接受了 ILAT 治疗,并在治疗后 8-30 个月进行了随访评估,每周接受 6-12.5 小时的治疗,持续 2-4 周。使用标准化的临床失语症测试工具,即亚琛失语症测试,发现 ILAT 治疗后患者的语言功能有显著改善,且可维持长达 2.5 年。在相对年轻的患者(<60 岁)中,改善情况相对更好地保留下来。沟通效果的评估也证实了强化治疗期间的改善,但长期稳定性的效果并不一致。本研究数据表明,ILAT 强化语言治疗的效果可以在治疗结束后持续 2.5 年。我们根据临床实践中从稀疏治疗向强化治疗模式转变的可能性,对这一新发现进行了讨论。