Department of Interventional Medicine, Zhangye Second People's Hospital, Zhangye City, Gansu, China.
Department of Pharmacy, Zhangye Second People's Hospital, Zhangye City, Gansu, China.
Medicine (Baltimore). 2021 Jul 9;100(27):e26454. doi: 10.1097/MD.0000000000026454.
There is no meta-analysis or review in the literature to compare and evaluate the difference and effectiveness of ultrasonic-accelerated thrombolysis (UAT) and catheter directed thrombolysis (CDT) in lower extremity deep vein thrombosis (DVT) patients. Therefore, we conducted this protocol of systematic review and meta-analysis to evaluate the efficacy between UAT and CDT for patients with lower extremity DVT.
We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols reporting guidelines to conduct this study. Reviewers will search the PubMed, Cochrane Library, Web of Science, and EMBASE online databases using the key phrases "deep venous thrombosis," "thrombolysis," and "ultrasound-accelerated" for all cohort studies published up to July 22, 2021. There is no restriction in the dates of publication or language in the search for the current review. The primary outcome is major bleeding. Secondary outcomes include health-related quality of life and complications such as recurrent venous thromboembolism, pulmonary embolism, in-stent thrombosis, and death. Review Manager software (v 5.4; Cochrane Collaboration) will be used for the meta-analysis. A P value of < .05 is considered to be statistically significant.
We hypothesized that these two methods would provide similar therapeutic benefits.
10.17605/OSF.IO/YZB3H.
目前尚无文献对超声辅助溶栓（UAT）和导管定向溶栓（CDT）治疗下肢深静脉血栓形成（DVT）患者的差异和疗效进行比较和评估的荟萃分析或综述。因此，我们制定了本系统评价和荟萃分析方案，以评估 UAT 和 CDT 治疗下肢 DVT 患者的疗效。
我们遵循系统评价和荟萃分析报告规范的首选报告项目（PRISMA）指南进行本研究。审查员将使用关键词“深静脉血栓形成”、“溶栓”和“超声加速”，在 PubMed、Cochrane 图书馆、Web of Science 和 EMBASE 在线数据库中搜索截至 2021 年 7 月 22 日发表的所有队列研究。目前的综述不限制搜索的日期或语言。主要结局是大出血。次要结局包括健康相关生活质量和并发症，如复发性静脉血栓栓塞、肺栓塞、支架内血栓形成和死亡。将使用 Review Manager 软件（版本 5.4；Cochrane 协作网）进行荟萃分析。P 值<.05 被认为具有统计学意义。
我们假设这两种方法会提供类似的治疗效果。
OSF 注册号：10.17605/OSF.IO/YZB3H。
