Uozumi H, Baba Y, Yasunaga T, Takahashi M
Department of Radiology, Kumamoto University, School of Medicine, Japan.
Radiat Med. 1987 Jul-Aug;5(4):121-30.
From January 1985 to October 1986, 25 tumors in 23 patients were treated with combined hyperthermia and radiation therapy. All of these tumors were recurrent tumors after initial radiation therapy, and were presumed to be radioresistant tumors on the basis of histological findings and poor response at 30-40 Gy. Heat was delivered using the radiofrequency of 13.56 MHz at 500 W or 1000 W. In combination with radiation therapy, hyperthermia was given at 42 degrees-43 degrees C for 30 minutes per fraction once a week for a total of four to five fractions (Protocol 1), or twice a week for a total of six to 10 fractions (Protocol 2). Hyperthermia once a week was as effective as twice a week. Small and diffuse tumors showed better results. Combined therapy was better than irradiation alone for suppression of these tumors. The adverse effects included three subcutaneous fat necroses with an associated lipoma in one case and three skin ulcers.
1985年1月至1986年10月，对23例患者的25个肿瘤进行了热疗与放射治疗相结合的治疗。所有这些肿瘤均为初始放疗后的复发性肿瘤，根据组织学检查结果以及在30 - 40 Gy剂量下反应不佳，推测为放射抗拒性肿瘤。使用13.56 MHz的射频，以500 W或1000 W的功率进行加热。与放射治疗联合时，热疗在42摄氏度至43摄氏度下进行，每次30分钟，每周一次，共进行四至五次（方案1），或每周两次，共进行六至十次（方案2）。每周进行一次热疗与每周进行两次热疗效果相同。体积小且呈弥漫性的肿瘤显示出更好的效果。联合治疗在抑制这些肿瘤方面优于单纯放疗。不良反应包括3例皮下脂肪坏死，其中1例伴有脂肪瘤，以及3例皮肤溃疡。
