Hiraoka M, Jo S, Dodo Y, Ono K, Takahashi M, Nishida H, Abe M
Cancer. 1984 Dec 15;54(12):2898-904. doi: 10.1002/1097-0142(19841215)54:12<2898::aid-cncr2820541214>3.0.co;2-b.
Clinical results of radiothermotherapy applied to 40 radioresistant tumors in 36 patients were reported. Hyperthermia was administered locally using two radiofrequency (RF) capacitive heating equipment systems developed in our institution under the collaboration of Yamamoto Vinyter Co. Ltd. Hyperthermia was given twice weekly immediately after irradiation. Intratumor temperatures of 41 degrees C to 44 degrees C were maintained for 30 to 60 minutes. Radiation doses varied from 32 Gy to 60 Gy. Of the 40 tumors treated, 21 (53%) showed complete response, 16 (40%) partial response, and 3 (7%) no response when the tumor response was assessed by tumor size measurement. Of eight patients who had matched tumors treated with either radiation alone or radiation plus hyperthermia, six patients showed better response in tumors treated with radiothermotherapy than in tumors treated with radiation alone. Skin reactions following radiothermotherapy and radiation alone were comparable. The tumor response was greatly dependent on the tumor size. Greater response was observed in small tumors, although histologic examinations and long-term follow-up studies revealed an excellent effect of radiothermotherapy on the large tumors as well as on the small tumors. Tumor responses correlated with tumor center temperatures but not with histologic features. Our clinical results indicate that RF hyperthermia combined with radiation has a therapeutic benefit in the treatment of radioresistant cancers.
报告了对36例患者的40个放射抗拒性肿瘤进行放射热疗的临床结果。使用我们机构在山本维尼特尔有限公司合作下开发的两个射频（RF）电容式加热设备系统进行局部热疗。热疗在每次放疗后立即每周进行两次。肿瘤内温度维持在41摄氏度至44摄氏度30至60分钟。放射剂量从32 Gy到60 Gy不等。在治疗的40个肿瘤中，通过测量肿瘤大小评估肿瘤反应时，21个（53%）显示完全缓解，16个（40%）部分缓解，3个（7%）无反应。在8例接受单纯放疗或放疗加高热治疗的配对肿瘤患者中，6例接受放射热疗的肿瘤比单纯接受放疗的肿瘤反应更好。放射热疗和单纯放疗后的皮肤反应相当。肿瘤反应在很大程度上取决于肿瘤大小。在小肿瘤中观察到更大的反应，尽管组织学检查和长期随访研究表明放射热疗对大肿瘤和小肿瘤都有很好的效果。肿瘤反应与肿瘤中心温度相关，但与组织学特征无关。我们的临床结果表明，射频热疗联合放疗在治疗放射抗拒性癌症方面具有治疗益处。
