Department of Synapse and Network Development, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, the Netherlands.
Department of Neuroregeneration, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, the Netherlands.
Cell Rep. 2021 Jul 6;36(1):109316. doi: 10.1016/j.celrep.2021.109316.
During early development, before the eyes open, synaptic refinement of sensory networks depends on activity generated by developing neurons themselves. In the mouse visual system, retinal cells spontaneously depolarize and recruit downstream neurons to bursts of activity, where the number of recruited cells determines the resolution of synaptic retinotopic refinement. Here we show that during the second post-natal week in mouse visual cortex, somatostatin (SST)-expressing interneurons control the recruitment of cells to retinally driven spontaneous activity. Suppressing SST interneurons increases cell participation and allows events to spread farther along the cortex. During the same developmental period, a second type of high-participation, retina-independent event occurs. During these events, cells receive such large excitatory charge that inhibition is overwhelmed and large parts of the cortex participate in each burst. These results reveal a role of SST interneurons in restricting retinally driven activity in the visual cortex, which may contribute to the refinement of retinotopy.
在早期发育过程中，眼睛睁开之前，感觉网络的突触细化取决于发育神经元自身产生的活动。在小鼠视觉系统中，视网膜细胞自发去极化并募集下游神经元进行爆发活动，其中募集的细胞数量决定了突触视性精化的分辨率。在这里，我们表明，在小鼠视觉皮层出生后的第二周，生长抑素 (SST) 表达中间神经元控制着对视网膜驱动的自发性活动的细胞募集。抑制 SST 中间神经元会增加细胞的参与度，并允许事件在皮层中传播得更远。在同一发育时期，第二种高参与度、与视网膜无关的事件发生。在这些事件中，细胞接收如此大的兴奋性电荷，以至于抑制作用被淹没，皮层的大部分区域都参与了每个爆发。这些结果揭示了 SST 中间神经元在限制视觉皮层中视网膜驱动活动中的作用，这可能有助于视性精化。
