• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高尿酸血症是结肠癌患者的不良预后因素。

Hyperuricemia is a Adverse Prognostic Factor for Colon Cancer Patients.

作者信息

Yan Jiang, Zhu Chuming

机构信息

Department of General Surgery, Liyang People's Hospital Affiliated to Nantong University, Liyang, 213300, People's Republic of China.

出版信息

Int J Gen Med. 2021 Jun 29;14:3001-3006. doi: 10.2147/IJGM.S314834. eCollection 2021.

DOI:10.2147/IJGM.S314834
PMID:34234529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8254611/
Abstract

OBJECTIVE

Hyperuricemia is linked to the prognosis of a number of cancers; however, its association with colon cancer survival has not been fully elucidated. To investigate whether hyperuricemia affects the prognosis of colon cancer, we conducted a retrospective study.

METHODS

The study included age- and sex-matched colon cancer patients, of whom 60 patients were diagnosed with hyperuricemia, and 120 patients did not have hyperuricemia. The overall survival (OS) and disease-free survival (DFS) of these patients were evaluated by Kaplan-Meier (K-M) analysis. The association between the survival of colon cancer patients and hyperuricemia was analyzed using the Cox regression method after adjusting for tumor stage and grade and vascular infiltration.

RESULTS

The K-M survival analysis supported that patients with hyperuricemia had poor OS ( for the Log rank test = 0.0008) and DFS. As demonstrated by the univariate analysis, the presence of hyperuricemia was correlated with decreased OS (HR = 2.09, = 0.002). Tumor grade and tumor stage were also found to be independent predictors for the prognosis of colon cancer patients. In addition, poor OS among patients with hyperuricemia was also confirmed in the adjusted analysis (HR = 1.94, = 0.005).

CONCLUSION

Hyperuricemia has an adverse effect on the prognosis and survival of patients with colon cancer. Further studies evaluating the cellular and molecular mechanisms are needed to validate the prognostic value of hyperuricemia in colon cancer.

摘要

目的

高尿酸血症与多种癌症的预后相关；然而，其与结肠癌生存的关联尚未完全阐明。为了研究高尿酸血症是否影响结肠癌的预后，我们进行了一项回顾性研究。

方法

该研究纳入了年龄和性别匹配的结肠癌患者，其中60例被诊断为高尿酸血症，120例没有高尿酸血症。通过Kaplan-Meier（K-M）分析评估这些患者的总生存期（OS）和无病生存期（DFS）。在调整肿瘤分期、分级和血管浸润后，使用Cox回归方法分析结肠癌患者生存与高尿酸血症之间的关联。

结果

K-M生存分析支持高尿酸血症患者的OS（对数秩检验=0.0008）和DFS较差。单因素分析表明，高尿酸血症的存在与OS降低相关（HR=2.09，=0.002）。还发现肿瘤分级和肿瘤分期是结肠癌患者预后的独立预测因素。此外，在调整分析中也证实了高尿酸血症患者的OS较差（HR=1.94，=0.005）。

结论

高尿酸血症对结肠癌患者的预后和生存有不利影响。需要进一步研究评估细胞和分子机制，以验证高尿酸血症在结肠癌中的预后价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2230/8254611/b09f9d329173/IJGM-14-3001-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2230/8254611/56d50e9eb1a3/IJGM-14-3001-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2230/8254611/b09f9d329173/IJGM-14-3001-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2230/8254611/56d50e9eb1a3/IJGM-14-3001-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2230/8254611/b09f9d329173/IJGM-14-3001-g0002.jpg

相似文献

1
Hyperuricemia is a Adverse Prognostic Factor for Colon Cancer Patients.高尿酸血症是结肠癌患者的不良预后因素。
Int J Gen Med. 2021 Jun 29;14:3001-3006. doi: 10.2147/IJGM.S314834. eCollection 2021.
2
[Prognostic value and initial exploratory research on TNM staging method of tumor deposits in stage III colon cancer].[Ⅲ期结肠癌中肿瘤结节TNM分期方法的预后价值及初步探索性研究]
Zhonghua Wei Chang Wai Ke Za Zhi. 2019 Dec 25;22(12):1152-1158. doi: 10.3760/cma.j.issn.1671-0274.2019.12.010.
3
Hyperuricemia has an adverse impact on the prognosis of patients with osteosarcoma.高尿酸血症对骨肉瘤患者的预后有不良影响。
Tumour Biol. 2016 Jan;37(1):1205-10. doi: 10.1007/s13277-015-3830-3. Epub 2015 Aug 18.
4
Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage III colon cancer.术前预后营养指数在III期结肠癌患者中的预后价值及其与全身炎症反应标志物的相关性
Chin J Cancer. 2017 Dec 21;36(1):96. doi: 10.1186/s40880-017-0260-1.
5
Prognostic significance of preoperative fibrinogen in patients with colon cancer.术前纤维蛋白原对结肠癌患者的预后意义。
World J Gastroenterol. 2014 Jul 14;20(26):8583-91. doi: 10.3748/wjg.v20.i26.8583.
6
Preoperative Leukocytosis as a Prognostic Marker in Endometrioid-Type Endometrial Cancer: A Single-Center Experience from Saudi Arabia.术前白细胞增多作为子宫内膜样型子宫内膜癌的预后标志物：来自沙特阿拉伯的单中心经验
Gulf J Oncolog. 2020 Jan;1(32):51-58.
7
Prognostic value of preoperative carcinoembryonic antigen/tumor size in rectal cancer.术前癌胚抗原/肿瘤大小对直肠癌的预后价值。
World J Gastroenterol. 2019 Sep 7;25(33):4945-4958. doi: 10.3748/wjg.v25.i33.4945.
8
Positive impact of the negative lymph node count on the survival rate of stage III colon cancer with pN1 and right-side disease.阴性淋巴结数量对伴有pN1和右侧病变的III期结肠癌生存率的积极影响。
J Cancer. 2019 Jan 29;10(4):1052-1059. doi: 10.7150/jca.23763. eCollection 2019.
9
Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival.中国627例右半结肠癌和左半结肠癌患者的比较：临床病理、复发及生存差异
Chronic Dis Transl Med. 2017 Mar 13;3(1):51-59. doi: 10.1016/j.cdtm.2017.02.004. eCollection 2017 Mar 25.
10
LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers.LAYN 是胃癌和结肠癌的预后生物标志物，并与免疫浸润相关。
Front Immunol. 2019 Jan 29;10:6. doi: 10.3389/fimmu.2019.00006. eCollection 2019.

引用本文的文献

1
Serum uric acid level can predict asymptomatic brain metastasis at diagnosis in patients with small cell lung cancer.血清尿酸水平可预测小细胞肺癌患者诊断时无症状性脑转移。
J Egypt Natl Canc Inst. 2024 Sep 30;36(1):28. doi: 10.1186/s43046-024-00235-1.
2
Prescribing cascades of antigout medications from thiazide diuretics in gout-naïve hypertensive adults receiving first-line pharmacological management.在接受一线药物治疗的初诊高血压成年痛风患者中，开具噻嗪类利尿剂至降尿酸药物的处方级联。
Sci Rep. 2024 Mar 28;14(1):7402. doi: 10.1038/s41598-024-58153-0.
3
Potential protective effects of increased serum uric acid concentration in sarcopenia: A meta-analysis and systematic review.

本文引用的文献

1
High expression of PLAC1 in colon cancer as a predictor of poor prognosis: A study based on TCGA data.PLAC1 在结肠癌中的高表达作为预后不良的预测指标：基于 TCGA 数据的研究。
Gene. 2020 Dec 30;763:145072. doi: 10.1016/j.gene.2020.145072. Epub 2020 Aug 19.
2
Exo70 is an independent prognostic factor in colon cancer.Exo70 是结肠癌的一个独立预后因素。
Sci Rep. 2017 Jul 11;7(1):5039. doi: 10.1038/s41598-017-05308-x.
3
The prognostic impact of uric acid in patients with severely decompensated acute heart failure.尿酸对严重失代偿性急性心力衰竭患者的预后影响。
血清尿酸浓度升高对肌少症的潜在保护作用：荟萃分析和系统评价。
Medicine (Baltimore). 2024 Mar 1;103(9):e37376. doi: 10.1097/MD.0000000000037376.
4
Elevated serum uric acid is associated with the risk of advanced staging and vascular involvement in patients with hepatoblastoma: a 14-year retrospective study.血清尿酸升高与肝母细胞瘤患者的晚期分期及血管受累风险相关：一项14年的回顾性研究
Front Oncol. 2023 Apr 14;13:1144349. doi: 10.3389/fonc.2023.1144349. eCollection 2023.
5
The relationship between serum uric acid and colorectal cancer: a prospective cohort study.血清尿酸与结直肠癌的关系：一项前瞻性队列研究。
Sci Rep. 2022 Oct 6;12(1):16677. doi: 10.1038/s41598-022-20357-7.
6
Potential Probiotic MJM60396 Prevents Hyperuricemia in a Multiple Way by Absorbing Purine, Suppressing Xanthine Oxidase and Regulating Urate Excretion in Mice.潜在益生菌MJM60396通过吸收嘌呤、抑制黄嘌呤氧化酶和调节小鼠尿酸排泄以多种方式预防高尿酸血症。
Microorganisms. 2022 Apr 20;10(5):851. doi: 10.3390/microorganisms10050851.
7
A Novel Cancer Stemness-Related Signature for Predicting Prognosis in Patients with Colon Adenocarcinoma.一种用于预测结肠腺癌患者预后的新型癌症干性相关特征。
Stem Cells Int. 2021 Oct 15;2021:7036059. doi: 10.1155/2021/7036059. eCollection 2021.
J Cardiol. 2016 Nov;68(5):384-391. doi: 10.1016/j.jjcc.2016.04.013. Epub 2016 May 31.
4
Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease.中国冠心病患者血清尿酸水平与死亡率之间的关联
Cardiology. 2016;134(3):347-56. doi: 10.1159/000443518. Epub 2016 Mar 18.
5
Effect of High-Grade Disease on Outcomes of Surgically Treated Colon Cancer.高级别疾病对手术治疗结肠癌预后的影响。
Ann Surg Oncol. 2016 Apr;23(4):1157-63. doi: 10.1245/s10434-015-4983-4. Epub 2015 Nov 20.
6
Serum Uric Acid Increases Risk of Cancer Incidence and Mortality: A Systematic Review and Meta-Analysis.血清尿酸增加癌症发病率和死亡率风险：一项系统评价和荟萃分析。
Mediators Inflamm. 2015;2015:764250. doi: 10.1155/2015/764250. Epub 2015 Oct 4.
7
Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects.痛风与癌症风险增加的关系：对三项涉及50358名受试者的前瞻性队列研究的综述
Mediators Inflamm. 2015;2015:680853. doi: 10.1155/2015/680853. Epub 2015 Oct 4.
8
Hyperuricemia has an adverse impact on the prognosis of patients with osteosarcoma.高尿酸血症对骨肉瘤患者的预后有不良影响。
Tumour Biol. 2016 Jan;37(1):1205-10. doi: 10.1007/s13277-015-3830-3. Epub 2015 Aug 18.
9
Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients.血尿酸水平与软组织肉瘤患者的临床结局相关。
Clin Chem Lab Med. 2015 Feb;53(3):493-7. doi: 10.1515/cclm-2014-0486.
10
Prognostic significance of the baseline serum uric acid level in non-small cell lung cancer patients treated with first-line chemotherapy: a study of the Turkish Descriptive Oncological Researches Group.一线化疗的非小细胞肺癌患者基线血清尿酸水平的预后意义：土耳其描述性肿瘤学研究组的一项研究
Med Oncol. 2014 Oct;31(10):217. doi: 10.1007/s12032-014-0217-z. Epub 2014 Sep 13.