Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC 27599, USA.
Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA 15203, USA.
Int J Environ Res Public Health. 2021 Jul 5;18(13):7209. doi: 10.3390/ijerph18137209.
This study examined the effect of estradiol-β-17 across the menstrual cycle (MC) during aerobic exercise on energy substrate utilization and oxidation. Thirty-two eumenorrheic (age = 22.4 ± 3.8 y (mean ± SD)), physically active women participated in two steady-state running sessions at 65% of VO, one during the early follicular and one during the luteal phase of the MC. Blood samples were collected at rest before each exercise session and analyzed for Estradiol-β-17 to confirm the MC phase. Carbohydrate (CHO) utilization and oxidation values were significantly lower ( < 0.05) in the luteal (utilization: 51.6 ± 16.7%; oxidation: 1.22 ± 0.56 g/min; effect size (ES) = 0.45, 0.27) than follicular phase (utilization: 58.2 ± 15.1%; oxidation: 1.38 ± 0.60 g/min) exercise sessions. Conversely, fat utilization and oxidation values were significantly ( < 0.05) higher in the luteal (utilization: 48.4 ± 16.7%; oxidation: 0.49 ± 0.19 g/min; ES = 0.45,0.28) than follicular phase (utilization: 41.8 ± 15.1%; oxidation: 0.41 ± 0.14 g/min). Estradiol-β-17 concentrations were significantly ( < 0.01) greater during the luteal (518.5 ± 285.4 pmol/L; ES = 0.75) than follicular phase (243.8 ± 143.2 pmol/L). Results suggest a greater use of fat and reduced amount of CHO usage during the luteal versus follicular phase, directly related to the change in resting estradiol-β-17. Future research should investigate the role these changes may play in female athletic performance.
这项研究考察了在月经周期（MC）中进行有氧运动时雌二醇-β-17 对能量底物利用和氧化的影响。32 名月经规律（年龄=22.4±3.8 岁（均值±标准差））、有规律运动的女性在 MC 的卵泡早期和黄体期各进行了两次 65%VO2 的稳态跑步。在每次运动前休息时采集血样，并分析雌二醇-β-17 以确认 MC 阶段。碳水化合物（CHO）利用率和氧化值在黄体期（利用率：51.6±16.7%；氧化：1.22±0.56 g/min；效应量（ES）=0.45，0.27）明显低于卵泡期（利用率：58.2±15.1%；氧化：1.38±0.60 g/min）运动期间（<0.05）。相反，黄体期（利用率：48.4±16.7%；氧化：0.49±0.19 g/min；ES=0.45，0.28）脂肪利用率和氧化值明显高于卵泡期（利用率：41.8±15.1%；氧化：0.41±0.14 g/min）（<0.05）。黄体期（518.5±285.4 pmol/L；ES=0.75）雌二醇-β-17 浓度明显高于卵泡期（243.8±143.2 pmol/L；<0.01）。结果表明，与卵泡期相比，黄体期脂肪的利用率更高，CHO 的利用率更低，这与静息雌二醇-β-17 的变化直接相关。未来的研究应该调查这些变化在女性运动表现中可能扮演的角色。
