Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Department of Pharmacy, Ningbo Hangzhou Bay Hospital, Ningbo, China.
Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Ann Palliat Med. 2021 Jun;10(6):6079-6091. doi: 10.21037/apm-21-87. Epub 2021 May 25.
Infectious disease caused by carbapenem-resistant Enterobacteriaceae (CRE) has become one of the most serious challenges due to its high morbidity and mortality and research on it has aroused great concern worldwide in the last decade. Thus, a bibliometric analysis of relevant publications is needed to identify the situation of current investigations and prioritize the future research areas.
The current study retrieved articles related to CRE published between 2010 and 2020 from the Web of Science core collection database. The search strategy syntax included "carbapenem-resistant Enterobacteriaceae", "carbapenem-resistant Klebsiella pneumoniae", "carbapenemase producing Enterobacteriaceae" and "carbapenemase producing Klebsiella pneumoniae" which were searched in both Medical Subject Headings (MeSH) and titles. A bibliometric analysis was conducted using VOSviewer, Bibliographic Item Co-Occurrence Matrix Builder, gCLUTO and other machine learning tools. Key words, subject terms, contributions as well as collaborations were assessed. Moreover, hot off the press and future research trends were demonstrated.
A total of 1,671 publications on CRE were finally included in the bibliometric analysis and 5 related theme clusters were identified which mainly focused on epidemiology, resistance mechanisms, antibiotics treatment and infection control. A total of 142 keywords occurred more than 5 times and the most frequent keyword was "carbapenem-resistant Enterobacteriaceae" with 247 occurrences and a total link strength of 559. The output on CRE has gradually increased during the last decade, and the USA has made the greatest contribution due to the 533 research papers. Agents that act against CRE, especially ceftazidime-avibactam (occurrences, 85; average publication year, 2018.26), and the early detection of CRE by genome sequencing techniques (occurrences, 97; average publication year, 2017.94) were emerging hot topics which would probably attract future research interest.
The bibliometric analysis revealed that development of antibacterial agents, early etiological detection and genome sequencing techniques were the hotspots and would probably direct the future research directions which would also facilitate a better understanding of the epidemiology of drug-resistant bacteria and implementing the antibiotic stewardship program.
由于碳青霉烯类耐药肠杆菌科（CRE）引起的传染病具有较高的发病率和死亡率，因此成为最严重的挑战之一，近十年来，其研究引起了全球的极大关注。因此，需要对相关出版物进行文献计量分析，以确定当前研究的情况，并确定未来的研究重点。
本研究从 Web of Science 核心合集数据库中检索了 2010 年至 2020 年间发表的与 CRE 相关的文章。检索策略语法包括“carbapenem-resistant Enterobacteriaceae”、“carbapenem-resistant Klebsiella pneumoniae”、“carbapenemase-producing Enterobacteriaceae”和“carbapenemase-producing Klebsiella pneumoniae”，这些术语在主题词（MeSH）和标题中均有检索。使用 VOSviewer、Bibliographic Item Co-Occurrence Matrix Builder、gCLUTO 和其他机器学习工具进行了文献计量分析。评估了关键词、主题词、贡献以及合作情况。此外，还展示了最新的研究趋势和未来的研究趋势。
最终纳入文献计量分析的 CRE 相关出版物共有 1671 篇，确定了 5 个相关主题集群，主要集中在流行病学、耐药机制、抗生素治疗和感染控制方面。共出现了 142 个出现频率超过 5 次的关键词，出现频率最高的关键词是“carbapenem-resistant Enterobacteriaceae”，出现了 247 次，总链接强度为 559。过去十年中，有关 CRE 的研究成果逐渐增加，美国由于发表了 533 篇研究论文，做出了最大的贡献。针对 CRE 的药物，尤其是头孢他啶-阿维巴坦（出现次数 85；平均发表年份 2018.26）和通过基因组测序技术早期检测 CRE（出现次数 97；平均发表年份 2017.94）是新兴的热点，可能会引起未来的研究兴趣。
文献计量分析表明，抗菌药物的开发、早期病因学检测和基因组测序技术是热点，可能会指导未来的研究方向，也有助于更好地了解耐药菌的流行病学，并实施抗生素管理计划。
