Mazloomi Sahar, Sheikh Nasrin, Sanoee Farimani Marzieh, Pilehvari Shamim
Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Int J Endocrinol. 2021 Jun 22;2021:9949753. doi: 10.1155/2021/9949753. eCollection 2021.
Chronic inflammation and oxidative stress conditions have been reported in women with polycystic ovary syndrome (PCOS). Peroxiredoxin 4 (Prx4) is a related antioxidant in insulin synthesis. We hypothesized that insulin resistance in these women is associated with total oxidant status (TOS) and inflammatory factors.
Two hundred three people including 104 PCOS patients and 99 healthy women, who were matched for age and body mass index (BMI), entered the study. Waist circumference of the participants was measured; serum glucose, lipid profile, insulin, Prx4, TOS, hs-CRP, and TNF- were also evaluated.
The Prx4 level was significantly lower in PCOS than in the control group. In addition, marked increase was observed in the concentration of TOS, hs-CRP, and TNF- in PCOS, compared to the healthy women. There was a positive correlation of TOS with hs-CRP, TNF-, and HOMA-IR. The risk of PCOS for subjects with high hs-CRP was 60 times greater than those who had low serum hs-CRP concentration; after performing multiple logistic regression analyses with the backward method, TNF- was considered as an effective biomarker to predict PCOS = 49.087 (all < 0.05).
This study identified increased oxidative stress and inflammation in PCOS; this may be due to decrease in the antioxidants, such as Prx4.
据报道，多囊卵巢综合征（PCOS）女性存在慢性炎症和氧化应激状况。过氧化物酶4（Prx4）是胰岛素合成中的一种相关抗氧化剂。我们推测这些女性的胰岛素抵抗与总氧化剂状态（TOS）和炎症因子有关。
203人纳入研究，其中包括104例PCOS患者和99例年龄及体重指数（BMI）相匹配的健康女性。测量了参与者的腰围；还评估了血清葡萄糖、血脂谱、胰岛素、Prx4、TOS、高敏C反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）。
PCOS患者的Prx4水平显著低于对照组。此外，与健康女性相比，PCOS患者的TOS、hs-CRP和TNF-α浓度显著升高。TOS与hs-CRP、TNF-α和稳态模型评估胰岛素抵抗（HOMA-IR）呈正相关。hs-CRP水平高的受试者患PCOS的风险比血清hs-CRP浓度低的受试者高60倍；采用向后法进行多因素逻辑回归分析后，TNF-α被认为是预测PCOS的有效生物标志物（比值比=49.087，所有P<0.05）。
本研究发现PCOS患者氧化应激和炎症增加；这可能是由于抗氧化剂如Prx4减少所致。
