Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Cell. 2021 Jul 8;184(14):3593-3594. doi: 10.1016/j.cell.2021.06.013.
How the microbiome and mucosal environment mediate homeostatic immunity in the skin is not well understood. In this issue of Cell, Lima-Junior and colleagues report that skin commensal bacteria induce endogenous retrovirus (ERV) expression and antiviral immune responses in keratinocytes, favoring the priming of beneficial commensal-specific T cell subsets that promote tissue homeostasis.
微生物组和黏膜环境如何介导皮肤的稳态免疫尚不清楚。在本期《细胞》杂志中，Lima-Junior 及其同事报告称，皮肤共生细菌诱导角质形成细胞中内源性逆转录病毒 (ERV) 的表达和抗病毒免疫反应，有利于有益共生特异性 T 细胞亚群的启动，从而促进组织稳态。
