Cassaro C M, Sampaio M U, Maeda N Y, Chamone D F, Sampaio C A
Instituto do Coração, Faculdade de Medicina, Universidade de S. Paulo, Brasil.
Thromb Res. 1987 Oct 1;48(1):81-7. doi: 10.1016/0049-3848(87)90348-3.
Platelet aggregation induced by ADP, collagen and adrenaline is increased by low concentrations of human plasma kallikrein, which does not cause aggregation by itself and inhibits the aggregation induced by arachidonic acid and Thrombofax in platelet rich plasma, and the aggregation induced by thrombin in washed platelets. At higher concentrations however, plasma kallikrein inhibits the aggregation induced by all the agents tested with platelet rich plasma and also causes a decrease in the aggregation induced in whole blood.
低浓度的人血浆激肽释放酶可增强由二磷酸腺苷（ADP）、胶原蛋白和肾上腺素诱导的血小板聚集，其本身不会引起聚集，且可抑制富含血小板血浆中由花生四烯酸和凝血酶诱导的聚集，以及洗涤血小板中由凝血酶诱导的聚集。然而，在较高浓度时，血浆激肽释放酶会抑制富含血小板血浆中所有测试试剂诱导的聚集，并导致全血中诱导的聚集减少。
