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斑马鱼作为一种新的模型来研究肿瘤与宿主代谢的串扰。

Zebrafish as a New Model to Study the Crosstalk between Tumor and Host Metabolism.

机构信息

Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

出版信息

Trends Cancer. 2021 Aug;7(8):661-663. doi: 10.1016/j.trecan.2021.06.006. Epub 2021 Jul 6.

DOI:10.1016/j.trecan.2021.06.006
PMID:34244124
Abstract

The mechanism of metabolic crosstalk between different tissues in the host remains poorly understood but is likely to play important roles in tumor growth and cachexia. A recent study from Naser, Jackstadt, et al. utilizes isotope tracing in a zebrafish melanoma model and finds that tumors secrete alanine into circulation, which is taken up by the liver and used for gluconeogenesis.

摘要

宿主不同组织之间的代谢串扰机制仍不清楚，但可能在肿瘤生长和恶病质中发挥重要作用。Naser、Jackstadt 等人最近的一项研究利用同位素示踪在斑马鱼黑色素瘤模型中发现，肿瘤将丙氨酸分泌到循环中，然后被肝脏摄取用于糖异生。

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