Russo Irene, Sartor Emma, Fagotto Laura, Colombo Anna, Tiso Natascia, Alaibac Mauro
Unit of Dermatology, University of Padua, Via Gallucci 4, 35128, Padua, Italy.
Department of Biology, University of Padua, Via U. Bassi 58/B, 35131, Padua, Italy.
Discov Oncol. 2022 Jun 17;13(1):48. doi: 10.1007/s12672-022-00511-3.
Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding human genetic disorders, including cancer. Interestingly, zebrafish skin shows several similarities to human skin, suggesting that this model organism is particularly suitable for the study of neoplastic and inflammatory skin disorders. This paper appraises the specific characteristics of zebrafish skin and describes the major applications of the zebrafish model in dermatological research.
最近，斑马鱼已成为医学研究中最重要的模式生物之一。多项研究证明，人类基因组与斑马鱼基因组高度相似，这促使人们将斑马鱼用作理解包括癌症在内的人类遗传疾病的模型。有趣的是，斑马鱼皮肤与人类皮肤有若干相似之处，这表明这种模式生物特别适合用于研究肿瘤性和炎症性皮肤疾病。本文评估了斑马鱼皮肤的具体特征，并描述了斑马鱼模型在皮肤病学研究中的主要应用。
