Li Li, Wazir Junaid, Huang Zhiqiang, Wang Yong, Wang Hongwei
State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu 210093, China.
Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, Jiangsu 210093, China.
Genes Dis. 2023 Sep 13;11(6):101080. doi: 10.1016/j.gendis.2023.101080. eCollection 2024 Nov.
Cancer cachexia is a multifactorial syndrome characterized by progressive weight loss and a disease process that nutritional support cannot reverse. Although progress has been made in preclinical research, there is still a long way to go in translating research findings into clinical practice. One of the main reasons for this is that existing preclinical models do not fully replicate the conditions seen in clinical patients. Therefore, it is important to understand the characteristics of existing preclinical models of cancer cachexia and pay close attention to the latest developments in preclinical models. The main models of cancer cachexia used in current research are allogeneic and xenograft models, genetically engineered mouse models, chemotherapy drug-induced models, Chinese medicine spleen deficiency models, zebrafish and Drosophila models, and cellular models. This review aims to revisit and summarize the commonly used animal models of cancer cachexia by evaluating existing preclinical models, to provide tools and support for translational medicine research.
癌症恶病质是一种多因素综合征，其特征为进行性体重减轻以及营养支持无法逆转的疾病进程。尽管临床前研究已取得进展，但将研究结果转化为临床实践仍有很长的路要走。造成这种情况的主要原因之一是现有的临床前模型不能完全复制临床患者的情况。因此，了解现有癌症恶病质临床前模型的特点并密切关注临床前模型的最新进展很重要。当前研究中使用的癌症恶病质主要模型有同种异体和异种移植模型、基因工程小鼠模型、化疗药物诱导模型、中医脾虚模型、斑马鱼和果蝇模型以及细胞模型。本综述旨在通过评估现有的临床前模型，重新审视和总结常用的癌症恶病质动物模型，为转化医学研究提供工具和支持。
