Müller H L
Hautarzt. 1978 Jan;29(1):27-30.
The evidence of humoral antibodies against yeasts can be a valuable help in the diagnosis of such infections. It is however necessary to use several sensitive methods, which complete one another in the detection of the different immunoglobulins. In the interpretation of the results the titer dynamic is decisive, especially in those patients whose antibody answer is suppressed by their disease and/or their therapeutic treatment. In most of the yeast infections Candida albicans can be used as antigen for the detection of antibodies because there is a strong relationship between the antigens of most of the yeasts important in human infections. C. krusei, C. pseudotropicalis and C. guilliermondii do not display enough common antigens to make a diagnosis against these yeasts possible with C. albicans. In that case homologous antigens have to be used. Cross reactions with other microorganisms are less frequent than usually supposed. Therefore so called false positive Candida titers have to be examined very carefully by clinical signs and culture methods.
针对酵母的体液抗体证据对这类感染的诊断可能有很大帮助。然而，有必要使用几种敏感方法，这些方法在检测不同免疫球蛋白时相互补充。在结果解读中，滴度动态起决定性作用，尤其是在那些抗体反应因疾病和/或治疗而受到抑制的患者中。在大多数酵母感染中，白色念珠菌可作为检测抗体的抗原，因为在人类感染中重要的大多数酵母的抗原之间存在密切关系。克柔念珠菌、近平滑念珠菌和季也蒙念珠菌没有足够的共同抗原，无法用白色念珠菌对这些酵母进行诊断。在这种情况下，必须使用同源抗原。与其他微生物的交叉反应比通常认为的要少。因此，对于所谓的假阳性念珠菌滴度，必须通过临床症状和培养方法进行仔细检查。
