Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Lübeckweg 2, 9723 HE, Groningen, The Netherlands.
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
J Autism Dev Disord. 2022 Jun;52(6):2747-2761. doi: 10.1007/s10803-021-05081-x. Epub 2021 Jul 10.
We studied the association of early-life environmental and child factors with disruptive behaviors in children with autistic traits around age 7, in the Avon Longitudinal Study of Parents and Children (n = 6,401). Logistic regression with the least absolute shrinkage and selection operator indicated that disruptive behaviors were associated with prenatal smoking, no seafood-consumption during pregnancy, breech presentation at delivery, neonatal feeding problems, low social-economic situation, suboptimal preschool family environment, maternal depression, maternal antisocial behavior, male sex, and difficult child temperament. Compared to controls, male sex, maternal depression, and suboptimal preschool family environment were related to autistic traits without disruptive behaviors. Thus, there may be a difference in early-life factors related to autism spectrum disorder with and without disruptive behaviors.
我们研究了 7 岁左右具有自闭症特征的儿童的早期环境和儿童因素与破坏性行为之间的关联，该研究基于埃文纵向父母和子女研究（n=6401）。最小绝对收缩和选择算子的逻辑回归表明，破坏性行为与产前吸烟、孕期不吃海鲜、分娩时臀位、新生儿喂养问题、社会经济状况低、学前家庭环境不佳、母亲抑郁、母亲反社会行为、男性和儿童气质困难有关。与对照组相比，男性、母亲抑郁和学前家庭环境不佳与无破坏性行为的自闭症特征有关。因此，自闭症谱系障碍伴或不伴破坏性行为的儿童可能具有不同的早期相关因素。
