腐草霉素，一种由吸水链霉菌产生的新型聚醚抗生素。

Carriomycin, a new polyether antibiotic produced by Streptomyces hygroscopicus.

作者信息

Imada A, Nozaki Y, Hasegawa T, Mizuta E, Igarasi S, Yoneda M

出版信息

J Antibiot (Tokyo). 1978 Jan;31(1):7-14. doi: 10.7164/antibiotics.31.7.

DOI:10.7164/antibiotics.31.7

Abstract

Carriomycin, a new polyether antibiotic, was isolated from culture broth of Streptomyces hygroscopicus strain T-42082. It is active against Gram-positive bacteria, several fungi, yeasts and mycoplasma. It is also coccidiostatic. The free acid of carriomycin occurs as colorless prisms having the molecular formula C47H80O15 (M.W. 885.15), m.p. 120 approximately 122 degrees C and [alpha]25D -0.5 in methanol. It has no characteristic absorption maxima in the ultraviolet spectrum. The presence of one carboxyl and three methoxy groups was observed from its infrared, PMR and CMR spectra.

摘要

卡里霉素是一种新型聚醚抗生素，从吸水链霉菌T-42082菌株的培养液中分离得到。它对革兰氏阳性菌、多种真菌、酵母和支原体具有活性。它也具有抗球虫作用。卡里霉素的游离酸为无色棱柱体，分子式为C47H80O15（分子量885.15），熔点约120至122℃，在甲醇中的比旋光度[α]25D -0.5。它在紫外光谱中没有特征吸收峰。从其红外光谱、质子磁共振谱和碳磁共振谱中观察到一个羧基和三个甲氧基的存在。