抗生素DE - 3936，一种与莫能菌素相同的聚醚抗生素。分类学、发酵、分离与特性鉴定。

Antibiotic DE-3936, a polyether antibiotic identical with lonomycin. Taxonomy, fermentation, isolation and characterization.

作者信息

Ohshima M, Ishizaki N, Abe N, Ukawa M, Marumoto Y

出版信息

J Antibiot (Tokyo). 1976 Apr;29(4):354-65. doi: 10.7164/antibiotics.29.354.

DOI:10.7164/antibiotics.29.354

Abstract

Antibiotic DE-3936 was isolated from the fermentation broth of a streptomycete No. 9735-1, which is identified as a strain of Streptomyces hygroscopicus. The antibiotic is a hydrophobic compound having the molecular formula of of C44H75O14Na and is active against Gram-positive bacteria, mycobacteria, mycoplasma and protozoa, especially coccidia. Its chemical and biological properties indicate that antibiotic DE-3936 belongs to the group of polyether antibiotics and is identical with lonomycin.

摘要

抗生素DE - 3936是从链霉菌9735 - 1的发酵液中分离得到的，该链霉菌被鉴定为吸水链霉菌菌株。这种抗生素是一种疏水化合物，分子式为C44H75O14Na，对革兰氏阳性菌、分枝杆菌、支原体和原生动物，尤其是球虫具有活性。其化学和生物学特性表明抗生素DE - 3936属于聚醚类抗生素，与离子霉素相同。