斑马鱼中苯酚及取代酚的代谢

The metabolism of phenol and substituted phenols in zebra fish.

Kasokat T, Nagel R, Urich K

Johannes Gutenberg-University, Institute of Zoology, Mainz, FR Germany.

Xenobiotica. 1987 Oct;17(10):1215-21. doi: 10.3109/00498258709167413.

Abstract

The metabolism of five phenols in zebra fish was studied after uptake from the medium. The results showed no qualitative differences to other Cyprinid fish species, only the oxidation rate seemed to be lower. 2. Phenyl glucuronide, phenyl sulphate, and quinol sulphate were identified as metabolites of phenol. 3. Identified metabolites of 2-cresol were 2-cresyl glucuronide, 2-cresyl sulphate, and 2-hydroxybenzoic acid in trace amounts. 4. Only the glucuronide and sulphate conjugates were detected as metabolites of 4-nitrophenol, 4-chlorophenol, and pentachlorophenol.

摘要

研究了斑马鱼从培养基中摄取五种酚类后的代谢情况。结果表明，与其他鲤科鱼类物种相比，在代谢性质上没有差异，只是氧化速率似乎较低。2. 苯葡糖苷酸、苯硫酸盐和喹啉硫酸盐被鉴定为苯酚的代谢产物。3. 2-甲酚的鉴定代谢产物为2-甲酚葡糖苷酸、2-甲酚硫酸盐和痕量的2-羟基苯甲酸。4. 仅葡糖苷酸和硫酸盐共轭物被检测为4-硝基苯酚、4-氯苯酚和五氯苯酚的代谢产物。