Department of Dermatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Immunol. 2021 Jun 24;12:698522. doi: 10.3389/fimmu.2021.698522. eCollection 2021.
Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as atopic dermatitis, food allergy, and asthma). Although two isoforms (short form and long form) of TSLP have been demonstrated in human tissues, the long form of TSLP (lfTSLP) is strongly implicated in the pathogenesis of allergies and cutaneous immune-mediated diseases. The immunomodulatory activity of lfTSLP varies widely, driving T helper (Th) cells polarizing Th2 and Th17 immune responses and inducing itch. Moreover, lfTSLP is closely associated with skin fibrosis, epidermal hyperplasia, angiogenesis, and homeostatic tolerogenic regulations. This review highlights significant progress from experimental and clinical studies on lfTSLP in cutaneous immune-mediated diseases (atopic dermatitis, psoriasis, bullous pemphigoid, systemic sclerosis, chronic spontaneous urticaria, Behçet's disease, vitiligo, rosacea, systemic lupus erythematosus, and alopecia areata). We also offer original insights into the pleiotropic properties of the cytokine TSLP in various pathophysiological conditions, with significant clinical implications of TSLP-targeted therapies for immune-mediated skin diseases in the future.
胸腺基质淋巴细胞生成素 (TSLP) 最初被证明在调节各种过敏疾病（如特应性皮炎、食物过敏和哮喘）的炎症反应中至关重要。尽管在人体组织中已经证明了 TSLP 的两种同工型（短型和长型），但 TSLP 的长型（lfTSLP）强烈暗示与过敏和皮肤免疫介导性疾病的发病机制有关。lfTSLP 的免疫调节活性差异很大，可驱动 T 辅助（Th）细胞向 Th2 和 Th17 免疫反应极化，并诱导瘙痒。此外，lfTSLP 与皮肤纤维化、表皮增生、血管生成和稳态耐受调节密切相关。这篇综述强调了 lfTSLP 在皮肤免疫介导性疾病（特应性皮炎、银屑病、大疱性类天疱疮、系统性硬化症、慢性自发性荨麻疹、贝切特病、白癜风、酒渣鼻、系统性红斑狼疮和斑秃）的实验和临床研究中的重要进展。我们还对细胞因子 TSLP 在各种病理生理条件下的多效性特性提供了独到的见解，这对未来针对免疫介导性皮肤病的 TSLP 靶向治疗具有重要的临床意义。
