Bansal Reema, Markan Ashish, Gautam Nitin, Guru Rashmi Ranjan, Lakshmi P V M, Katoch Deeksha, Agarwal Aniruddha, Singh Mini P, Suri Vikas, Mohindra Ritin, Sahni Neeru, Bhalla Ashish, Malhotra Pankaj, Gupta Vishali, Puri G D
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Hospital Administration, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Front Med (Lausanne). 2021 Jun 24;8:681942. doi: 10.3389/fmed.2021.681942. eCollection 2021.
To detect retinal involvement in coronavirus disease 2019 (COVID-19) patients in acute and convalescent phase by their fundus screening. In a prospective, cross-sectional, observational study (July-November 2020), 235 patients (142 acute and 93 convalescent phase) underwent fundus screening in a tertiary care center in North India. For convalescent phase, "hospitalized" patients (73) were screened at least 2 weeks after hospital discharge, and "home-isolated" patients (20) were screened 17 days after symptom onset/COVID-19 testing. None in acute phase showed any retinal lesion that could be attributed exclusively to COVID-19. Five patients (5.38%) in convalescent phase had cotton wool spots (CWSs) with/without retinal hemorrhage, with no other retinal finding, and no visual symptoms, seen at a median of 30 days from COVID-19 diagnosis. CWSs (and retinal hemorrhages) were an incidental finding in COVID-19, detected only in the convalescent phase. These patients were much older (median age = 69 years) than the average age of our sample and had systemic comorbidities (diabetes mellitus, hypertension, etc.). We propose the term "COVID-19 retinopathy" to denote the presence of CWSs at the posterior pole, occasionally associated with intraretinal hemorrhages, in the absence of ocular inflammation in patients with a history of COVID-19 disease.
通过眼底筛查检测2019冠状病毒病（COVID-19）患者急性期和恢复期的视网膜受累情况。在一项前瞻性、横断面观察性研究（2020年7月至11月）中，235例患者（142例急性期和93例恢复期）在印度北部的一家三级医疗中心接受了眼底筛查。对于恢复期患者，“住院”患者（73例）在出院后至少2周进行筛查，“居家隔离”患者（20例）在症状出现/COVID-19检测后17天进行筛查。急性期患者均未出现任何可明确归因于COVID-19的视网膜病变。恢复期有5例患者（5.38%）出现棉絮斑（CWSs）伴/不伴视网膜出血，无其他视网膜病变，也无视觉症状，这些情况在COVID-19诊断后的中位30天被发现。CWSs（以及视网膜出血）是COVID-19中的偶然发现，仅在恢复期被检测到。这些患者的年龄比我们样本的平均年龄大得多（中位年龄 = 69岁），并且有全身性合并症（糖尿病、高血压等）。我们提出“COVID-19视网膜病变”这一术语，用于表示有COVID-19病史的患者在无眼部炎症的情况下，后极部出现CWSs，偶尔伴有视网膜内出血。
