Wehling M, Kuhls S, Witzgall H, Kuhnle U, Armanini D, Theisen K
Medizinische Klinik Innenstadt and Kinderklinik, University of Munich, FRG.
Acta Endocrinol (Copenh). 1987 Dec;116(4):555-60. doi: 10.1530/acta.0.1160555.
In vitro effects of aldosterone have been described with regard to the intracellular sodium and potassium concentrations of human mononuclear leukocytes. In the present paper the in vitro effect of aldosterone on the intracellular sodium and potassium of human mononuclear leukocytes in 6 patients with primary aldosteronism was investigated. Except for one patient with elevated intracellular electrolytes, sodium and potassium in mononuclear leukocytes of patients with aldosteronism without incubation were within the range for normals. In the patients, no significant change of intracellular sodium or potassium was observed during incubation with or without aldosterone (1.4 nmol/l), whereas in normals, the loss of sodium and potassium during incubation without aldosterone was prevented by 1.4 nmol/l aldosterone. This insensitivity to aldosterone indicates that intracellular electrolytes in mononuclear leukocytes of patients with primary aldosteronism are kept in normal ranges by mechanism which are independent of mineralocorticoids and may represent the cellular correlate to the renal 'escape' phenomenon in aldosteronism.
关于醛固酮对人单核白细胞细胞内钠和钾浓度的体外作用已有描述。在本文中，研究了醛固酮对6例原发性醛固酮增多症患者人单核白细胞细胞内钠和钾的体外作用。除1例细胞内电解质升高的患者外，未孵育的醛固酮增多症患者单核白细胞中的钠和钾在正常范围内。在这些患者中，无论有无醛固酮（1.4 nmol/l）孵育期间，细胞内钠或钾均未观察到显著变化，而在正常人中，1.4 nmol/l醛固酮可防止无醛固酮孵育期间钠和钾的流失。对醛固酮的这种不敏感性表明，原发性醛固酮增多症患者单核白细胞中的细胞内电解质通过独立于盐皮质激素的机制保持在正常范围内，这可能代表醛固酮增多症中肾脏“逃逸”现象的细胞相关性。
