Laboratory of Molecular Nutrition and Immunity, Institute of Animal Nutrition, Northeast Agricultural University, Harbin, Heilongjiang 150030, People's Republic of China.
College of Animal Science and Veterinary Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, People's Republic of China.
J Agric Food Chem. 2021 Jul 21;69(28):7884-7897. doi: 10.1021/acs.jafc.1c02257. Epub 2021 Jul 12.
This study investigated the effects of oleanolic acid (OA) on hepatic lipid metabolism and gut-liver axis homeostasis in an obesity-related non-alcoholic fatty liver disease (NAFLD) nutritional animal model and explored possible molecular mechanisms behind its effects. The results revealed that OA ameliorated the development of metabolic disorders, insulin resistance, and hepatic steatosis in obese rats. Meanwhile, OA restored high-fat-diet (HFD)-induced intestinal barrier dysfunction and endotoxin-mediated induction of toll-like-receptor-4-related pathways, subsequently inhibiting endotoxemia and systemic inflammation and balancing the homeostasis of the gut-liver axis. OA also reshaped the composition of the gut microbiota of HFD-fed rats by reducing the Firmicutes/Bacteroidetes ratio and increasing the abundance of butyrate-producing bacteria. Our results support the applicability of OA as a treatment for obesity-related NAFLD through its anti-inflammatory, antioxidant, and prebiotic integration responses mediated by the gut-liver axis.
本研究旨在探讨齐墩果酸（OA）对肥胖相关非酒精性脂肪性肝病（NAFLD）营养性动物模型肝内脂质代谢和肠-肝轴稳态的影响，并探讨其作用的可能分子机制。结果表明，OA 可改善肥胖大鼠的代谢紊乱、胰岛素抵抗和肝脂肪变性。同时，OA 恢复了高脂肪饮食（HFD）诱导的肠道屏障功能障碍和内毒素介导的 toll 样受体 4 相关途径的诱导，从而抑制内毒素血症和全身炎症，平衡肠-肝轴的稳态。OA 还通过减少厚壁菌门/拟杆菌门的比例和增加丁酸产生菌的丰度，重塑 HFD 喂养大鼠的肠道微生物群落组成。我们的研究结果支持 OA 通过肠-肝轴介导的抗炎、抗氧化和益生元整合反应，作为治疗肥胖相关 NAFLD 的一种应用。
