Functional Neurosurgery Research Center, Shohada-e Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Functional Neurosurgery, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Parkinsonism Relat Disord. 2021 Aug;89:90-92. doi: 10.1016/j.parkreldis.2021.07.002. Epub 2021 Jul 8.
Parkinson's disease (PD) patients may be at increased risk of Covid-19 mortality due to the nature of their disease or underlying conditions.
The information of 12,909 Covid-19 patients who were hospitalized during the last eleven months were collected from the data depository of two referral university hospitals. Eighty-seven of these patients were diagnosed with PD, and thirty-one of these PD patients died because of Covid-19. 2132 other deaths occurred in these centers, related to Covid-19 of non-PD patients. Fisher exact test, Chi-square test, and Principle component analysis were used for statistical analysis.
The mortality among PD patients and other hospitalized patients was 35.6% and 19.8%, respectively, and the difference between the mortality of these two groups was found to be statistically significant (p-value<0.01). The mean age of PD patients who passed away was 77.06 ± 7.46, and it was not significantly different from that of alive PD patients (p-value>0.05). Alzheimer's disease as an underlying condition was more frequent in deceased PD patients in comparison to survived PD patients, and this difference was found to be statistically significant (p-value<0.01).
PD patients possess a higher rate of Covid-19 mortality in comparison with other patients hospitalized for Covid-19. PD pathophysiology, advanced age, underlying conditions, and health systems' efficacy may play an essential role in such an outcome.
由于疾病本身或潜在疾病的性质，帕金森病（PD）患者感染新冠病毒后死亡的风险可能会增加。
从两家转诊大学医院的数据存储库中收集了 12909 名在过去十一个月内因新冠病毒住院的患者的信息。其中 87 名患者被诊断为 PD，31 名 PD 患者因新冠病毒死亡。在这些中心还发生了 2132 例与非 PD 患者的新冠病毒相关的其他死亡。使用 Fisher 确切检验、卡方检验和主成分分析进行统计分析。
PD 患者和其他住院患者的死亡率分别为 35.6%和 19.8%，两组死亡率之间的差异具有统计学意义（p 值<0.01）。去世的 PD 患者的平均年龄为 77.06±7.46，与存活的 PD 患者的平均年龄无显著差异（p 值>0.05）。与存活的 PD 患者相比，患有阿尔茨海默病等潜在疾病的 PD 患者在死亡患者中更为常见，这种差异具有统计学意义（p 值<0.01）。
与因新冠病毒住院的其他患者相比，PD 患者的新冠病毒死亡率更高。PD 的病理生理学、高龄、潜在疾病和卫生系统的效能可能在这种结果中起重要作用。
