载有甘草查尔酮A的固体脂质纳米粒可提高抗血吸虫活性及…… （原文此处不完整）

Licochalcone A-loaded solid lipid nanoparticles improve antischistosomal activity and .

作者信息

Silva Lívia Mara, Marconato Danielle Gomes, Nascimento da Silva Marcos Paulo, Barbosa Raposo Nádia Rezende, Faria Silva Facchini Gabriela de, Macedo Gilson Costa, Teixeira Fernanda de Sá, Barbosa da Silveira Salvadori Maria Cecília, Faria Pinto Priscila de, Moraes Josué de, Pittella Frederico, Da Silva Filho Ademar Alves

机构信息

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora - MG, 36036-900, Brazil.

Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora - MG, 36036-900, Brazil.

出版信息

Nanomedicine (Lond). 2021 Aug;16(19):1641-1655. doi: 10.2217/nnm-2021-0146. Epub 2021 Jul 14.

DOI:10.2217/nnm-2021-0146

PMID:34256609

Abstract

To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid nanoparticles (L-SLNs) and evaluate the L-SLNs and against . LicoA was obtained by chromatographic fractionation and encapsulated in SLNs by a modified high shear homogenization method. L-SLNs showed high encapsulation efficiency, with satisfactory particle size, polydispersity index and Zeta potential. Transmission electron microscopy revealed that L-SLNs were rounded and homogenously distributed. Toxicity studies revealed that SLNs decreased the hemolytic and cytotoxic properties of LicoA. Treatment with L-SLNs showed efficacy against . L-SLNs are efficient in reducing worm burden and SLNs may be a promising delivery system for LicoA to treat infections.

摘要

从甘草中分离出甘草查尔酮A（LicoA），制备负载LicoA的固体脂质纳米粒（L-SLNs），并评估L-SLNs对……的作用。通过色谱分离法获得LicoA，并采用改良的高剪切均质法将其包封于固体脂质纳米粒中。L-SLNs表现出高包封率，具有令人满意的粒径、多分散指数和Zeta电位。透射电子显微镜显示L-SLNs呈圆形且分布均匀。毒性研究表明，固体脂质纳米粒降低了LicoA的溶血和细胞毒性特性。用L-SLNs治疗显示出对……的疗效。L-SLNs在减轻虫负荷方面有效，并且固体脂质纳米粒可能是用于治疗……感染的LicoA的一种有前景的递送系统。