Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Radiodiagnosis Center, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Pathol Oncol Res. 2021 Apr 1;27:628942. doi: 10.3389/pore.2021.628942. eCollection 2021.
Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. In this study, we examined the presence of () in oral-digestive tract tumors by immunohistochemistry (IHC) and PCR and analyzed the correlation between detection and clinicopathological characteristics and prognosis of oral and esophageal carcinoma. The IHC results showed that the positive rates of were 60.00, 46.00, 20.00, 6.67, and 2.86% in oral, esophagus, cardiac, stomach, and colorectal cancer tissues, respectively. Likewise, PCR results showed rates of 56.00, 42.00, 16.67, 3.33, and 2.86%, respectively. The two methods were consistent, and the value was 0.806, < 0.001. In addition, expression was significantly correlated with lymph node metastasis and the clinical stages of oral and esophageal cancer ( < 0.05). The overall survival rate of the undetected group (86, 50%) was significantly higher than that of the detected group (57, 14%) for oral and esophageal cancer, respectively. In conclusion, the detection rate of showed a decreasing trend in oral-digestive tract tumors. Detection with was associated with poor prognosis for oral and esophageal cancer.
越来越多的证据表明，特定细菌感染与某些恶性肿瘤的发展之间存在因果关系。在这项研究中，我们通过免疫组织化学（IHC）和 PCR 检查了口腔消化道肿瘤中 () 的存在，并分析了 () 检测与口腔和食管癌的临床病理特征和预后之间的相关性。IHC 结果显示，在口腔、食管、贲门、胃和结直肠癌细胞组织中， 的阳性率分别为 60.00%、46.00%、20.00%、6.67%和 2.86%。同样，PCR 结果显示的阳性率分别为 56.00%、42.00%、16.67%、3.33%和 2.86%。两种方法一致， 值为 0.806， < 0.001。此外， 表达与口腔和食管癌的淋巴结转移和临床分期显著相关（ < 0.05）。未检测到 () 的口腔和食管癌患者的总生存率（分别为 86，50%）明显高于检测到 () 的患者（57，14%）。总之，口腔消化道肿瘤中 的检出率呈下降趋势。口腔和食管癌中 () 的检测与预后不良相关。
