Dekker Tobias E G, van der Heijden Heleen Susanne, Schirmbeck Frederike, van Amelsvoort Therese, Bartels-Velthuis Agna A, Simons Claudia J P, de Haan Lieuwe, Vermeulen Jentien M
Early Psychosis Department, Amsterdam UMC (location AMC), Department of Psychiatry, Amsterdam, the Netherlands.
Arkin Institute for Mental Health, Amsterdam, the Netherlands.
Schizophr Res Cogn. 2021 Jun 30;26:100206. doi: 10.1016/j.scog.2021.100206. eCollection 2021 Dec.
In patients with psychotic disorders, both tobacco smoking and deficits in social cognition and social functioning are highly prevalent. However, little is known about their relationship in psychosis. The authors sought to evaluate the multi-cross-sectional and longitudinal associations between tobacco smoking, social cognition and social functioning in a large prospective study.
This study was performed within the Genetic Risk and Outcome of Psychosis (GROUP) Study, a cohort study conducted in patients with non-affective psychosis (N = 1074), their unaffected siblings (N = 1047) and healthy controls (N = 549). At baseline, three years and six years of follow-up, data on tobacco smoking (using the Composite International Diagnostic Review), social cognition (emotion processing and theory of mind) and social functioning were collected. To assess associations between tobacco smoking and social cognition or social functioning, multivariate linear mixed-effects models and multiple linear regression models were used. Bonferroni correction for multiple testing was applied.
A significant positive association was found between smoking and emotion processing (as part of social cognition) in the patient group (estimate = 1.96, SE = 0.6, p = 0.003). However, smoking was significantly negatively associated with participating in pro-social activities compared with non-smoking (estimate = −2.55, SE = 0.9, p = 0.004). Change in smoking behaviour was not associated with social cognition or social functioning in the longitudinal analyses.
Findings indicate that smoking patients with a non-affective psychotic disorder slightly outperformed their non-smoking peers on a task on social cognition, but participated less in pro-social activities. Commencement or cessation of smoking was not related to social cognition or functioning.
在患有精神障碍的患者中，吸烟以及社会认知和社会功能缺陷都非常普遍。然而，关于它们在精神病中的关系却知之甚少。作者试图在一项大型前瞻性研究中评估吸烟、社会认知和社会功能之间的多横断面和纵向关联。
本研究在精神病遗传风险与结局（GROUP）研究中进行，该队列研究针对非情感性精神病患者（N = 1074）、其未患病的兄弟姐妹（N = 1047）和健康对照者（N = 549）开展。在基线、随访三年和六年时，收集了关于吸烟（使用综合国际诊断复查）、社会认知（情绪加工和心理理论）和社会功能的数据。为评估吸烟与社会认知或社会功能之间的关联，使用了多元线性混合效应模型和多元线性回归模型。对多重检验进行了Bonferroni校正。
在患者组中，发现吸烟与情绪加工（作为社会认知的一部分）之间存在显著正相关（估计值 = 1.96，标准误 = 0.6，p = 0.003）。然而，与不吸烟相比，吸烟与参与亲社会活动显著负相关（估计值 = -2.55，标准误 = 0.9，p = 0.004）。在纵向分析中，吸烟行为的变化与社会认知或社会功能无关。
研究结果表明，患有非情感性精神病障碍的吸烟患者在一项社会认知任务上的表现略优于不吸烟的同龄人，但参与亲社会活动的程度较低。开始或停止吸烟与社会认知或功能无关。
