Oderinde Oluwaseyi M, Shirvani Shervin M, Olcott Peter D, Kuduvalli Gopinath, Mazin Samuel, Larkin David
RefleXion Medical, Inc, Hayward, CA, USA.
Clin Transl Radiat Oncol. 2021 Apr 17;29:106-112. doi: 10.1016/j.ctro.2021.04.003. eCollection 2021 Jul.
This is a summary of the design and concept of the RefleXion X1, a system for biology-guided radiotherapy (BgRT). This system is a multi-modal tomography (PET, fan-beam kVCT, and MVD) treatment machine that utilizes imaging and therapy planes for optimized beam delivery of IMRT, SBRT, SRS, and BgRT radiotherapy regimens. For BgRT delivery specifically, annihilation photons emanating outward from a PET-avid tumor are used to guide the delivery of beamlets of radiation to the tumor at sub-second latency. With the integration of PET detectors, rapid beam-station delivery, real-time tracking, and high-frequency multi-leaf collimation, the BgRT system has the potential to deliver a highly conformal treatment to malignant lesions while minimizing dose to surrounding healthy tissues. Furthermore, the potential use of a single radiotracer injection to guide radiotherapy to multiple targets opens avenues for debulking in advanced and metastatic disease states.
这是RefleXion X1的设计与概念总结，它是一种生物引导放射治疗（BgRT）系统。该系统是一台多模态断层扫描（PET、扇形束千伏CT和MVD）治疗机，利用成像和治疗平面来优化调强放疗（IMRT）、立体定向体部放疗（SBRT）、立体定向放射外科（SRS）和BgRT放疗方案的束流输送。具体对于BgRT输送而言，从PET高摄取肿瘤向外发射的湮灭光子用于以亚秒级延迟引导辐射子束向肿瘤的输送。通过集成PET探测器、快速束流驻留输送、实时跟踪和高频多叶准直，BgRT系统有潜力在将周围健康组织的剂量降至最低的同时，对恶性病变进行高度适形的治疗。此外，单次放射性示踪剂注射用于引导对多个靶点进行放射治疗的潜在用途为晚期和转移性疾病状态下的减瘤开辟了途径。
