Schweitzer S A, Morgan D J
Department of Anaesthesia, St Vincent's Hospital, Fitzroy, Victoria, Australia.
Anaesth Intensive Care. 1987 Nov;15(4):425-30. doi: 10.1177/0310057X8701500412.
Postoperative analgesia and plasma concentrations of bupivacaine were evaluated in six patients receiving intermittent epidural bupivacaine for a period of 72 hours following large bowel surgery. Repeated doses were administered every hour by a new automatic, specially designed pump. Venous plasma bupivacaine concentrations showed accumulation for up to 48-60 hours during administration and were mostly less than 2 micrograms/ml except in an elderly, frail patient in whom a peak of 3.9 micrograms/ml was observed. This convenient, low-dose, pulsed technique provided excellent analgesia although special care may be necessary in the elderly and frail patient if potentially toxic levels are to be avoided.
对六名接受间歇性硬膜外布比卡因的患者进行了术后镇痛和血浆布比卡因浓度评估，这些患者在大肠手术后接受了72小时的布比卡因治疗。通过一个新的专门设计的自动泵每小时给予重复剂量。静脉血浆布比卡因浓度在给药期间显示累积达48 - 60小时，除了一名老年体弱患者观察到峰值为3.9微克/毫升外，大多数浓度低于2微克/毫升。这种方便、低剂量、脉冲式技术提供了良好的镇痛效果，尽管如果要避免潜在的中毒水平，对于老年体弱患者可能需要特别小心。
