Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi.
Medical College, Aga Khan University, Karachi.
Monaldi Arch Chest Dis. 2022 May 24;93(1). doi: 10.4081/monaldi.2022.2230.
The role of vitamin D as an immunosuppressant and anti-inflammatory has been studied previously for different pathologies in different populations globally. Relationships between serum vitamin D levels and its effect on asthma exacerbations in the adolescent asthma population are not well studied in this region. Therefore, this study was conducted to determine the vitamin D status in pediatric and adolescent asthma patients, and its association with asthma exacerbations. A retrospective study was conducted at The Aga Khan University Hospital from 2016 to 2020. Children and adolescents who were diagnosed and admitted with acute asthma exacerbations and who had at least one measurement of 25 hydroxy-vitamin D (25 OHD) were included in the study. Serum vitamin D levels were documented for enrolled patients and their past 2-year data was analyzed for asthma exacerbations, mean length of stay per admission, and admission plus length of stay at High Dependency Unit. 114 patients were included in the study. 41 patients (35.96%) were found to be vitamin D deficient, 38 patients (33.3%) were vitamin D insufficient, and 35 patients (30.7%) were labeled as vitamin D sufficient. The average number of exacerbations per year was significantly high in vitamin D deficient group (2.82±1.11) in comparison with insufficient (2.05±0.92) and sufficient groups (1.37±0.59) (p<0.001). Vitamin D deficiency is related to an increased number of annual asthma exacerbations, length of stay per admission, and admission into High Dependency Unit (HDU).
先前已有研究表明，维生素 D 具有免疫抑制和抗炎作用，在全球不同人群的不同疾病中都有研究。在该地区，血清维生素 D 水平与青少年哮喘患者哮喘恶化之间的关系尚未在该人群中得到充分研究。因此，本研究旨在确定儿科和青少年哮喘患者的维生素 D 状况及其与哮喘恶化的关系。本研究为回顾性研究，于 2016 年至 2020 年在阿迦汗大学医院进行。研究纳入了被诊断为急性哮喘加重并入院且至少有一次 25 羟维生素 D（25 OHD）测量值的儿童和青少年。记录了纳入患者的血清维生素 D 水平，并对其过去 2 年的哮喘恶化、每次入院的平均住院时间以及入住重症监护病房（HDU）的时间进行了分析。本研究共纳入 114 例患者。其中 41 例（35.96%）患者维生素 D 缺乏，38 例（33.3%）患者维生素 D 不足，35 例（30.7%）患者维生素 D 充足。与维生素 D 不足组（2.82±1.11）相比，维生素 D 缺乏组患者每年哮喘恶化的次数明显更高（2.05±0.92）和充足组（1.37±0.59）（p<0.001）。维生素 D 缺乏与每年哮喘恶化次数增加、每次入院时间延长和入住 HDU 有关。
